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Titolo:
CYTOPROTECTIVE AND ANTISECRETORY ACTIVITY OF A RANITIDINE-ZINC COMPLEX
Autore:
CONCHILLO A; MOLA C; NAVARRO C; BRAVO L; BULBENA O;
Indirizzi:
LAB VINAS SA,DEPT PHARMACOL,TORRENTE VIDALET 29 E-08012 BARCELONA SPAIN LAB VINAS SA,DEPT CHEM RES E-08012 BARCELONA SPAIN
Titolo Testata:
Prostaglandins, leukotrienes and essential fatty acids
fascicolo: 6, volume: 52, anno: 1995,
pagine: 393 - 397
SICI:
0952-3278(1995)52:6<393:CAAAOA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-MUCOSAL RESISTANCE; PEPTIC-ULCER; ACEXAMATE; RAT; PROSTAGLANDINS; INJURY; PATHOGENESIS; DISEASE; THERAPY; ALCOHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Conchillo et al., "CYTOPROTECTIVE AND ANTISECRETORY ACTIVITY OF A RANITIDINE-ZINC COMPLEX", Prostaglandins, leukotrienes and essential fatty acids, 52(6), 1995, pp. 393-397

Abstract

The effects of a ranitidine-zinc complex and ranitidine alone were compared in three different experimental models (pyloric ligation, ethanol and indomethacin) of gastric ulceration in the rat. In the pyloric ligation model, the ranitidine-zinc complex (50, 100 and 150 mg/kg p.o.) showed antiulcerogenic activity similar to that observed with equimolar doses of ranitidine (35, 70 and 105 mg/kg p.o.). Both the ranitidine-zinc complex and ranitidine significantly reduced (p < 0.05) gastric acid secretion in a dose-dependent manner. The protective effect ofthe ranitidine-zinc complex (100 and 150 mg/kg p.o.) against gastric damage developing after p.o. administration of absolute ethanol or indomethacin was enhanced (p < 0.05) with respect to that obtained with equimolar doses of ranitidine (70 and 105 mg/kg p.o.). The presence of zinc in the ranitidine-zinc complex does not interfere with the antisecretory effects of ranitidine on the gastric mucosa, while it confers an additional cytoprotective action to the final compound.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 03:53:51