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Titolo:
DEVELOPMENTAL MATURATION OF PINEAL-GLAND FUNCTION - SYNCHRONIZED CREMINDUCIBILITY AND ADRENERGIC-STIMULATION
Autore:
STEHLE JH; FOULKES NS; PEVET P; SASSONECORSI P;
Indirizzi:
INST GENET,1 RUE LAURENT FRIES F-67404 ILLKIRCH GRAFFENS FRANCE CNRS F-67000 STRASBOURG FRANCE INST GENET & BIOL MOLEC & CELLULAIRE F-67404 ILLKIRCH GRAFFENS FRANCE KLINIKUM JOHANN WOLFGANG GOETHE UNIV,ZENTRUM MORPHOL D-60590 FRANKFURT GERMANY
Titolo Testata:
Molecular endocrinology
fascicolo: 6, volume: 9, anno: 1995,
pagine: 706 - 716
SICI:
0888-8809(1995)9:6<706:DMOPF->2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; SUPRACHIASMATIC NUCLEUS; N-ACETYLTRANSFERASE; CIRCADIAN CLOCK; MELATONIN RHYTHM; RAT PINEALOCYTES; LIGHT; PROTEIN; TRANSCRIPTION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Stehle et al., "DEVELOPMENTAL MATURATION OF PINEAL-GLAND FUNCTION - SYNCHRONIZED CREMINDUCIBILITY AND ADRENERGIC-STIMULATION", Molecular endocrinology, 9(6), 1995, pp. 706-716

Abstract

The cAMP response element modulator (CREM) gene encodes multiple activators and repressors of cAMP-responsive transcription. Differential splicing generates a developmental switch in CREM function during spermatogenesis, while the use of an alternative promoter is responsible for the production of a cAMP-inducible transcriptional repressor, ICER (inducible cAMP early repressor). The ICER promoter is strongly inducible by cAMP because of the presence of four tandemly repeated cAMP response elements. Furthermore, ICER negatively autoregulates the ICER promoter activity, thus generating a feedback loop. CREM constitutes an early response gene of the cAMP pathway in several neuroendocrine cells. We have previously shown that CREM is highly expressed in the adult rat pineal gland at nighttime. Here, we show that the only additional site of rhythmic ICER expression within the photoneuroendocrine systemis the lamina intercalaris. Ontogenetically, the ICER day-night switch and cAMP inducibility mature in the pineal gland at the end of the first postnatal week. Importantly, this correlates with the onset of melatonin synthesis and the establishment of functional adrenergic innervation, At this developmental phase we document a significant increasein protein kinase A levels, thus suggesting that ICER inducibility reflects a complete maturation of the cAMP-dependent signaling pathway at the nuclear level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 19:58:39