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Titolo:
CHRONOLOGY OF P53 PROTEIN ACCUMULATION IN GASTRIC CARCINOGENESIS
Autore:
CRAANEN ME; BLOK P; DEKKER W; OFFERHAUS GJA; TYTGAT GNJ;
Indirizzi:
NETHERLANDS CANC INST,DEPT MED ONCOL,PLESMANLAAN 121 1066 CX AMSTERDAM NETHERLANDS ACAD MED CTR,DEPT GASTROENTEROL AMSTERDAM NETHERLANDS ACAD MED CTR,DEPT PATHOL AMSTERDAM NETHERLANDS WESTEINDE ZIEKENHUIS,DEPT PATHOL THE HAGUE NETHERLANDS KENNEMER GASTHUIS LOCATIE EG,DEPT INTERNAL MED HAARLEM NETHERLANDS
Titolo Testata:
Gut
fascicolo: 6, volume: 36, anno: 1995,
pagine: 848 - 852
SICI:
0017-5749(1995)36:6<848:COPPAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; GENE-MUTATIONS; PROGNOSTIC-SIGNIFICANCE; INTESTINAL METAPLASIA; MONOCLONAL-ANTIBODIES; SYDNEY SYSTEM; CANCER; EXPRESSION; CARCINOMA; OVEREXPRESSION;
Keywords:
P53 PROTEIN ACCUMULATION; EARLY GASTRIC CANCER; LAUREN CLASSIFICATION; GROWTH PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Craanen et al., "CHRONOLOGY OF P53 PROTEIN ACCUMULATION IN GASTRIC CARCINOGENESIS", Gut, 36(6), 1995, pp. 848-852

Abstract

p53 Protein accumulation in early gastric carcinoma was studied in relation to the histological type (Lauren classification) and the type of growth pattern, including the chronology of p53 protein accumulationduring carcinogenesis. Forty five, paraffin embedded gastrectomy specimens from early carcinomas were examined for the presence of chronic atrophic gastritis, subtypes of intestinal metaplasia, and dysplasia. The Lauren type and the type of growth pattern were reassessed for allearly carcinomas. p53 Protein accumulation was examined using the monoclonal antibody DO-7. Complete absence of p53 protein accumulation was observed in normal gastric mucosa, chronic atrophic gastritis, and intestinal metaplasia, irrespective of subtype. In gastric dysplasia (one mild, two moderate, and one severe), only severe dysplasia was p53 positive. Intestinal type (n=20) and diffuse type early gastric carcinomas (n=25) were p53 positive in 70% and 52% of cases, respectively. Both tumour types differed significantly in the percentage of p53 positive tumour cells per tumour (p<0.01) and in staining intensity (p<0.05). No significant difference in p53 protein accumulation was found between early carcinomas with different types of growth pattern. It is concluded that p53 protein accumulation usually reflecting missense p53 gene mutation - seems to be a late event in gastric carcinogenesis. Moreover, it is suggested that missense p53 gene mutation occurs in a final pathway common to both intestinal and diffuse type of early gastric carcinoma. Finally, the types of growth pattern do not seem to differ in p53 protein accumulation.

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Documento generato il 25/01/21 alle ore 16:27:01