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Titolo:
HIGH HELICOBACTER-PYLORI NUMBERS ARE ASSOCIATED WITH LOW ERADICATION RATE AFTER TRIPLE THERAPY
Autore:
MOSHKOWITZ M; KONIKOFF FM; PELED Y; SANTO M; HALLAK A; BUJANOVER Y; TIOMNY E; GILAT T;
Indirizzi:
ICHILOV HOSP,TEL AVIV MED CTR,DEPT GASTROENTEROL,6 WEIZMAN ST IL-64239 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Gut
fascicolo: 6, volume: 36, anno: 1995,
pagine: 845 - 847
SICI:
0017-5749(1995)36:6<845:HHNAAW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER DISEASE; DOUBLE-BLIND TRIAL; DUODENAL-ULCER; CAMPYLOBACTER-PYLORI; BREATH TEST; INFECTION; RELAPSE;
Keywords:
HELICOBACTER PYLORI; UREA BREATH TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Moshkowitz et al., "HIGH HELICOBACTER-PYLORI NUMBERS ARE ASSOCIATED WITH LOW ERADICATION RATE AFTER TRIPLE THERAPY", Gut, 36(6), 1995, pp. 845-847

Abstract

This study tested the influence of pretreatment bacterial density on the eradication rate of Helicobacter pylori with triple therapy. One hundred and thirty two patients with endoscopically confirmed H pylori positive, duodenal ulcer or antral gastritis were treated with triple therapy (colloidal bismuth/metronidazole/amoxicillin) for two weeks. Pretreatment urease activity was assessed by the C-14-urea breath test (UBT) in all patients. The mean (SD) pretreatment UBT concentration was similar in patients with duodenal ulcers (318.4 (175.0)) and patients with antral gastritis (288.9 (165.5)). Overall eradication of H pylori was achieved in 85 of 132 patients (64.4%), but was significantly different between patients with high, intermediate, or low pretreatmenturease activity (37.5%, 69.5%, and 87.8% respectively). The mean post-treatment UBT value of patients in whom eradication failed was in direct correlation with the pretreatment UBT values. In conclusion, bacterial density, as assessed by urease activity, is an important factor in predicting H pylori eradication. It is suggested that the pretreatment UBT has the potential to identify patients who require modificationof the standard therapeutic regimen.

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Documento generato il 28/03/20 alle ore 23:18:20