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Titolo:
MORPHOMETRIC AND ELECTRICAL-PROPERTIES OF RECONSTRUCTED HIPPOCAMPAL CA3 NEURONS RECORDED IN-VIVO
Autore:
TURNER DA; LI XG; PYAPALI GK; YLINEN A; BUZSAKI G;
Indirizzi:
DUKE UNIV,MED CTR,DEPT NEUROSURG,BOX 3807 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT NEUROBIOL DURHAM NC 27710 VET ADM MED CTR DURHAM NC 27710 RUTGERS STATE UNIV,CTR MOLEC & BEHAV NEUROSCI NEWARK NJ 07102
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 356, anno: 1995,
pagine: 580 - 594
SICI:
0021-9967(1995)356:4<580:MAEORH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRAMIDAL NEURONS; DENDRITIC MORPHOLOGY; RAT HIPPOCAMPUS; VOLTAGE-CLAMP; CELL-TYPES; DENTATE; REGION; MODEL; MEMORY; SYSTEM;
Keywords:
INTRACELLULAR LABELING; BIOCYTIN; NEURONAL RECONSTRUCTIONS; MORPHOMETRY; NEURONAL MODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Turner et al., "MORPHOMETRIC AND ELECTRICAL-PROPERTIES OF RECONSTRUCTED HIPPOCAMPAL CA3 NEURONS RECORDED IN-VIVO", Journal of comparative neurology, 356(4), 1995, pp. 580-594

Abstract

CA3 pyramidal neurons were stained with biocytin during intracellularrecording in rat hippocampus in vivo and reconstructed using a computer-based system. The in vivo CA3 neurons were characterized primarily according to their proximity to the hilus and secondarily with respectto the septotemporal location. Neurons measured in CA3a (n = 4), in CA3b (n = 4), and in posterior/ventral locations (n = 3) had the greatest dendritic lengths (19.8, 19.1, and 26.8 mm on average, respectively). Cells closer to the hilus showed much shorter dendritic lengths, averaging 10.4 mm for CA3c neurons (n = 4) and 11.6 mm for zone 3 neurons (n = 2). Half of the cells showed more than one major apical dendrite, and dendritic trees were highly variable even within CA3 subregions. The mean electrotonic length for these cell groups averaged between 0.30 lambda (CA3c) and 0.45 lambda (posterior/ventral), assuming a constant specific-membrane resistivity of 60 K Omega-cm(2). These CA3 neurons form a database of reconstructed neurons for further morphometricand electrical modelling studies. The large degree of variability between individual CA3 neurons indicates that both dendritic and electrical properties should be specifically calculated for each cell rather than assuming a ''typical'' morphology. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 15/08/20 alle ore 19:55:35