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Titolo:
IMMUNOCYTOCHEMICAL LOCALIZATION OF THE RENAL NEUTRAL AND BASIC-AMINO-ACID TRANSPORTER IN RAT ADRENAL-GLAND, BRAIN-STEM, AND SPINAL-CORD
Autore:
NIRENBERG MJ; TATE SS; MOSCKOVITZ R; UDENFRIEND S; PICKEL VM;
Indirizzi:
CORNELL UNIV,COLL MED,DEPT NEUROL & NEUROSCI NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT BIOCHEM NEW YORK NY 10021 ROCHE INST MOLEC BIOL,ROCHE RES CTR,DEPT NEUROSCI NUTLEY NJ 07110
Titolo Testata:
Journal of comparative neurology
fascicolo: 4, volume: 356, anno: 1995,
pagine: 505 - 522
SICI:
0021-9967(1995)356:4<505:ILOTRN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; PRESUMPTIVE TERMINAL PROCESSES; ROSTRAL VENTROLATERAL MEDULLA; NUCLEUS-TRACTUS-SOLITARIUS; XENOPUS-LAEVIS OOCYTES; NERVE-FIBERS; CATECHOLAMINERGIC NEURONS; AREA POSTREMA; INSITU HYBRIDIZATION; EFFERENT PROJECTIONS;
Keywords:
UPTAKE; MONOAMINE; CATECHOLAMINE; VESICLE; ULTRASTRUCTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Nirenberg et al., "IMMUNOCYTOCHEMICAL LOCALIZATION OF THE RENAL NEUTRAL AND BASIC-AMINO-ACID TRANSPORTER IN RAT ADRENAL-GLAND, BRAIN-STEM, AND SPINAL-CORD", Journal of comparative neurology, 356(4), 1995, pp. 505-522

Abstract

A neutral and basic amino acid transporter (NBAT) cloned from rat kidney was recently localized to enteroendocrine cells and enteric neurons. We used an antibody directed against a synthetic peptide representing a putative extracellular domain of NBAT to determine whether this transporter was also present in other endocrine and neural tissues, including rat adrenal gland, brainstem, and spinal cord. Abundant, highlygranular labeling for NBAT was observed in the cytoplasm of chromaffin and ganglion cells in the adrenal medulla. A small population of intensely labeled varicose processes was also seen in both the cortex andthe medulla of the adrenal gland. More numerous, intensely labeled varicose processes were detected in brainstem and spinal cord nuclei, including the locus coeruleus, rostral ventrolateral medulla, nuclei of the solitary tract, dorsal motor nucleus of the vagus, and intermediolateral cell column of the thoracic spinal cord. Significant perikaryallabeling for NBAT was only detected in brainstem and spinal cord following intraventricular colchicine treatment, which increased the number, distribution, and intensity of NBAT-immunolabeled cells. These NBAT-immunoreactive perikarya were most numerous in the locus coeruleus, rostral ventrolateral medulla, nuclei of the solitary tract, and raphe nuclei. Ultrastructural examination of the nuclei of the solitary tract of normal rats showed that NBAT was localized predominantly to axon terminals. Within these labeled terminals, NBAT was associated with large dense core vesicles and discrete segments of plasma membrane. The observed localization of NBAT suggests that this renal specific amino acid transporter subserves a role as a vesicular or plasmalemmal transporter in monoamine-containing cells, including chromaffin cells and autonomic neurons. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:01:02