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Titolo:
SINGLE CA2-ACTIVATED K+ CHANNELS IN CULT URED KIDNEY-CELLS VERO()
Autore:
KAZACHENKO VN; GELETYUK VI; CHEMERIS NK; FESENKO EE;
Indirizzi:
RUSSIAN ACAD SCI,INST CELL BIOPHYS PUSHCHINO 142292 MOSCOW REG RUSSIA
Titolo Testata:
Biofizika
fascicolo: 6, volume: 41, anno: 1996,
pagine: 1322 - 1331
SICI:
0006-3029(1996)41:6<1322:SCKCIC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
RUS
Soggetto:
ACTIVATED POTASSIUM CHANNELS; RAT SKELETAL-MUSCLE; SMALL CONDUCTANCE; CALCIUM; BLOCKADE; MEMBRANE; KINETICS; BILAYERS; NEURONS; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
V.N. Kazachenko et al., "SINGLE CA2-ACTIVATED K+ CHANNELS IN CULT URED KIDNEY-CELLS VERO()", Biofizika, 41(6), 1996, pp. 1322-1331

Abstract

Using the patch voltage-clamp method (<<inside-out>> mode) propertiesof single Ca2+-activated K+ channels in cultured kidney cell Vero were studied. Two types of kinetically distinct channels (fast and slow) were found. The fast and slow channels differ by single channel conductance, kinetic parameters, characteristics of interaction with Ca2+, and voltage dependency degree of the kinetics parameters, but are similar in ionic selectivity in respect to monovalent cations. It was foundthat the channel conductance varies from patch to patch between 140 and 230 pS. Average values of single channel open duration and an apparent dissociation constant were correlated with the single channel conductance. The relationship was found: the more the conductance the lesser the open time duration and more the dissociation constant. The datasuggest that there is almost continuous spectrum of subtypes of the Ca2+-activated K+ channels, the fast and slow channels being extreme groups of this spectrum. The data are regarded from the viewpoint of theclustery hypothesis.

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Documento generato il 30/11/20 alle ore 00:06:42