Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOSE-RESPONSE COMPARISONS OF 5 LUNG SURFACTANT FACTOR (LSF) PREPARATIONS IN AN ANIMAL-MODEL OF ADULT-RESPIRATORY-DISTRESS-SYNDROME (ARDS)
Autore:
HAFNER D; BEUME R; KILIAN U; KRASZNAI G; LACHMANN B;
Indirizzi:
BYK GULDEN LOMBERG GMBH,DEPT RESP PHARMACOL,POSTBOX 100310 D-78403 CONSTANCE GERMANY ERASMUS UNIV ROTTERDAM,DEPT ANAESTHESIOL ROTTERDAM NETHERLANDS
Titolo Testata:
British Journal of Pharmacology
fascicolo: 3, volume: 115, anno: 1995,
pagine: 451 - 458
SICI:
0007-1188(1995)115:3<451:DCO5LS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPIRATORY PRESSURE PEEP; EXOGENOUS SURFACTANT; VENTILATION; REPLACEMENT; LAVAGE; FLUID;
Keywords:
ADULT RESPIRATORY DISTRESS SYNDROME (ARDS)-MODEL; DOSE-RESPONSE COMPARISONS; SYNTHETIC LUNG SURFACTANT FACTOR; BOVINE LUNG SURFACTANT FACTOR; RECOMBINANT LUNG SURFACTANT FACTOR; GAS EXCHANGE; SURFACTANT PROTEIN C (SP-C);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D. Hafner et al., "DOSE-RESPONSE COMPARISONS OF 5 LUNG SURFACTANT FACTOR (LSF) PREPARATIONS IN AN ANIMAL-MODEL OF ADULT-RESPIRATORY-DISTRESS-SYNDROME (ARDS)", British Journal of Pharmacology, 115(3), 1995, pp. 451-458

Abstract

1 We have examined the effects of five different lung surfactant factor (LSF) preparations in the rat lung lavage model. In this model repetitive lung lavage leads to lung injury with some similarities to adult respiratory distress syndrome with poor gas exchange and protein leakage into the alveolar spaces. These pathological sequelae can be reversed by LSF instillation soon after lavage. 2 The tested LSF preparations were: two bovine: Survanta and Alveofact: two synthetic: Exosurf and a protein-free phospholipid based LSF (PL-LSF) and one Recombinant LSF at doses of 25, 50 and 100 mg kg(-1) body weight and an untreated control group. 3 Tracheotomized rats (10-12 ptr dose) were pressure-controlled ventilated (Siemens Servo Ventilator 900C) with 100% oxygen at a respiratory rate of 30 breaths min(-1), inspiration expiration ratio of 1 : 2, peak inspiratory pressure (PIP) of 28 cmH(2)O at positiveend-expiratory pressure (PEEP) of 8 cmH(2)O. Two hours after LSF administration, PEEP and in parallel PIP was reduced from 8 to 6 (1st reduction), from 6 to 3 (2nd reduction) and from 3 to 0 cmH(2)O (3rd reduction). 4 Partial arterial oxygen pressure (PaO2, mmHg) at 5 min and 120 min after LSF administration and during the 2nd PEEP reduction (PaO2(PEEP23/3)) were used for statistical comparison. All LSF preparationscaused a dose-dependent increase for the PaO2(120 degrees), whereas during the 2nd PEEP reduction only bovine and recombinant LSF exhibiteddose-dependency. Exosurf did not increase PaO2 after administration of the highest dose. At the highest dose Exosurf exerted no further improvement but rather a tendency to relapse. The bovine and the Recombinant LSF are superior to both synthetic LSF preparations. 5 In this animal model and under the described specific ventilatory settings, even between bovine LSF preparations there are detectable differences that are pronounced when compared to synthetic LSF without any surfactant proteins. We conclude that the difference between bovine and synthetic LSF preparations can be overcome by addition of the surfactant proteinC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:49:19