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Titolo:
EVIDENCE FOR CHRONIC MORBILLIVIRUS INFECTION IN THE MEDITERRANEAN STRIPED DOLPHIN (STENELLA-COERULEOALBA)
Autore:
DOMINGO M; VILAFRANCA M; VISA J; PRATS N; TRUDGETT A; VISSER I;
Indirizzi:
VET FAC BELLATERRA BARCELONA,DEPT PATHOL E-08193 BARCELONA SPAIN QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM BELFAST BT7 1NN ANTRIM NORTH IRELAND NATL INST PUBL HLTH & ENVIRONM PROTECT 3720 BA BILTHOVEN NETHERLANDS
Titolo Testata:
Veterinary microbiology
fascicolo: 2-4, volume: 44, anno: 1995,
pagine: 229 - 239
SICI:
0378-1135(1995)44:2-4<229:EFCMII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBACUTE SCLEROSING PANENCEPHALITIS; MEASLES-VIRUS; MATRIX PROTEINS; EXPRESSION; DISTEMPER; PORPOISES; DEFECT; GENES; SEAL;
Keywords:
MORBILLIVIRUS; DOLPHIN; DISTEMPER; ENCEPHALITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Domingo et al., "EVIDENCE FOR CHRONIC MORBILLIVIRUS INFECTION IN THE MEDITERRANEAN STRIPED DOLPHIN (STENELLA-COERULEOALBA)", Veterinary microbiology, 44(2-4), 1995, pp. 229-239

Abstract

In the summer of 1990 an epizootic infection caused by a morbillivirus (DMV) killed several thousand striped dolphins (Stenella coeruleoalba) in the Mediterranean Sea. In 1991 and 1992 the epizootic reached Italian and Greek waters. The infection by DMV in the acute period of the epizootic caused encephalitis, pneumonia and depletion of lymph nodes. After 1990, the systemic infection apparently disappeared from the Catalonian coast, giving way to cases of chronic infection of the CNS. Dolphins that died between 1991 and May 1994 were necropsied, and investigated for lesions due to DMV, and for the presence of morbillivirus antigen in tissues. Encephalitis occurred in 6 dolphins in which DMVantigen was demonstrated in the CNS and which were without lesions orantigen in other, non-nervous tissues. Inflammatory lesions, gliosis,and DMV antigen decreased in density and amount from cerebral grey matter, through the thalamic areas to the medulla oblongata. The cerebellum was usually spared. Lesions consisted of non-suppurative encephalitis, with diffuse gliosis and glial nodules and neuronophagia, and loss of neurons. Perivascular cuffing of lymphocytes and plasma cells waspresent in the cerebral cortex and the white matter beneath the cortex. Multinucleate syncytia were not detected in any of the dolphins. The haemagglutinin of DMV was detected mainly in neurons in the cerebralcortical areas. There was no clear relationship between the presence and amount of DMV antigen and the density or chronicity of lesions. Viral inclusions were seen in haematoxylin and eosin stained sections in3/6 dolphins, principally in the nucleus and the cytoplasm of neurons. In the immunoperoxidase stained sections, dense granular deposits ofchromogen, similar to viral inclusions, were evident in all 6 dolphins. The change in the distribution of lesions and of DMV antigen, from systemic to localized in the CNS, and the clustering of systemic DMV infections in the first four months of the epizootic, giving rise to sporadic occurrence of local CNS infection in the subsequent four years,as well as the chronic nature of the CNS lesions, which closely resembles subacute sclerosing panencephalitis, strongly support the existence of a chronic morbillivirus infection in the striped dolphin, as a delayed consequence of the 1990 epizootic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:06:55