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Titolo:
EFFECT OF METHIONINE-ENKEPHALIN ON NATURAL-KILLER-CELL AND CYTOTOXIC T-LYMPHOCYTE ACTIVITY IN MICE INFECTED WITH INFLUENZA-A VIRUS
Autore:
BURGER RA; WARREN RP; HUFFMAN JH; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,DEPT BIOL,DIV BIOMED RES LOGAN UT 84322 UTAH STATE UNIV,INST ANTIVIRAL RES LOGAN UT 84322
Titolo Testata:
Immunopharmacology and immunotoxicology
fascicolo: 2, volume: 17, anno: 1995,
pagine: 323 - 334
SICI:
0892-3973(1995)17:2<323:EOMONA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELENAZOFURIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Burger et al., "EFFECT OF METHIONINE-ENKEPHALIN ON NATURAL-KILLER-CELL AND CYTOTOXIC T-LYMPHOCYTE ACTIVITY IN MICE INFECTED WITH INFLUENZA-A VIRUS", Immunopharmacology and immunotoxicology, 17(2), 1995, pp. 323-334

Abstract

Methionine enkephalin (Met-Enk) was evaluated for efficacy as an immune activator and potential therapeutic agent in influenza A/NWS/33 (H1N1) viral infections in female BALB/C mice. Influenza infection was induced intranasally with an approximate 90% lethal dose of virus and mice were treated intraperitoneally with doses of 10, 3 and 1 mg/kg/day,with treatments given 24 h pre-, 24 h post- and 72 h post-virus exposure. Splenocytes were assayed for natural killer cell (NK) and cytotoxic T lymphocyte (CTL) activity al time periods 76, 96 and 120 h post virus exposure. The 10 mg/kg dosage level significantly increased both CTL and NK activity at all time periods assayed. Other treatment schedules included single doses of 20, 10 and 3 mg/kg/day Met-Enk at either24 h post- or 72 h post-virus exposure, with highly significant increases in NK and CTL activity noted after the latter treatment. The results of this study demonstrate the immunomodulatory effects of Met-Enk on NK and CTL in influenza infected mice and suggest a potential for therapeutic applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:10:53