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Titolo:
SOMATODENDRITIC EXPRESSION OF AN IMMEDIATE-EARLY GENE IS REGULATED BYSYNAPTIC ACTIVITY
Autore:
LINK W; KONIETZKO U; KAUSELMANN G; KRUG M; SCHWANKE B; FREY U; KUHL D;
Indirizzi:
UNIV HAMBURG,ZMNH,CTR MOLEC NEUROBIOL,MARTINISTR 52,PAV 22 D-20246 HAMBURG GERMANY UNIV HAMBURG,ZMNH,CTR MOLEC NEUROBIOL D-20246 HAMBURG GERMANY OV GUERICKE UNIV,FAC MED,INST PHARMACOL & TOXICOL D-39120 MAGDEBURG GERMANY FED INST NEUROBIOL D-39008 MAGDEBURG GERMANY
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 12, volume: 92, anno: 1995,
pagine: 5734 - 5738
SICI:
0027-8424(1995)92:12<5734:SEOAIG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN-SYNTHESIS; VISUAL-CORTEX; GLUTAMATE-RECEPTOR; NERVOUS-SYSTEM; DENTATE GYRUS; APLYSIA LEADS; MEMORY; SPECTRIN; RNA;
Keywords:
HIPPOCAMPUS; NEURONAL PLASTICITY; SEIZURE; LONG-TERM POTENTIATION; GENE INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
W. Link et al., "SOMATODENDRITIC EXPRESSION OF AN IMMEDIATE-EARLY GENE IS REGULATED BYSYNAPTIC ACTIVITY", Proceedings of the National Academy of Sciences of the United Statesof America, 92(12), 1995, pp. 5734-5738

Abstract

Trans-synaptic activation of gene expression is linked to long-term plastic adaptations in the nervous system, To examine the molecular program induced by synaptic activity, we have employed molecular cloning techniques to identify an immediate early gene that is rapidly inducedin the brain. We here report the entire nucleotide sequence of the cDNA, which encodes an open reading frame of 396 amino acids, Within thehippocampus, constitutive expression was low. Basal levels of expression in the cortex were high but can be markedly reduced by blockade ofN-methyl-D-aspartate receptors. By contrast, synaptic activity induced by convulsive seizures increased mRNA levels in neurons of the cortex and hippocampus. High-frequency stimulation of the perforant path resulted in long-term potentiation and a spatially confined dramatic increase in the level of mRNA in the granule cells of the ipsilateral dentate gyrus, Transcripts were localized to the soma and to the dendrites of the granule cells, The dendritic localization of the transcripts offers the potential for local synthesis of the protein at activated postsynaptic sites and may underlie synapse-specific modifications during long-term plastic events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:20:59