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Titolo:
COMPARISON OF HEMODYNAMIC-EFFECTS AND PLASMA CYCLIC GUANOSINE-MONOPHOSPHATE OF NICORANDIL AND NITROGLYCERIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE
Autore:
TSUTAMOTO T; KINOSHITA M; HISANAGA T; MAEDA Y; MAEDA K; WADA A; FUKAI D; YOSHIDA S;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 52021 JAPAN
Titolo Testata:
The American journal of cardiology
fascicolo: 16, volume: 75, anno: 1995,
pagine: 1162 - 1165
SICI:
0002-9149(1995)75:16<1162:COHAPC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOSORBIDE DINITRATE; TRANSDERMAL NITROGLYCERIN; NITRATE TOLERANCE; ANGINA-PECTORIS; REVERSAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Tsutamoto et al., "COMPARISON OF HEMODYNAMIC-EFFECTS AND PLASMA CYCLIC GUANOSINE-MONOPHOSPHATE OF NICORANDIL AND NITROGLYCERIN IN PATIENTS WITH CONGESTIVE-HEART-FAILURE", The American journal of cardiology, 75(16), 1995, pp. 1162-1165

Abstract

Hemodynamic tolerance has been observed within several hours of continuous infusion of nitroglycerin (NTG). We examined the hemodynamic parameters as well as femoral arterial and venous cyclic guanosine monophosphate (cGMP) concentrations during intravenous infusion of NTG or nicorandil, a nitrate and potassium channel opener, in patients with congestive heart failure. Doses of NTG or nicorandil were titrated to achieve a greater than or equal to 25% reduction in pulmonary capillary wedge pressure (PCWP) within 1 hour, and the infusion was maintained ata constant rate for 24 hours. The reduction in PCWP and mean arterialblood pressure was identical after a 1-hour infusion of either NTG ornicorandil. In the NTG group, PCWP and mean blood pressure were not significantly different from the baseline value at 12 hours, but in tile nicorandil group PCWP and mean blood pressure remained significantlylower than the preinfusion value for 24 hours. The cGMP production with NTG (assessed by the difference between the plasma arterial and venous cGMP level) paralleled the changes in PCWP, suggesting that the plasma arteriovenous cGMP difference is a biochemical indicator of nitrate tolerance. Although the sustained decrease in PCWP was observed in the nicorandil group, cGMP production with nicorandil was also attenuated at 24 hours of continuous infusion. These findings suggest that the absence of the hemodynamic tolerance af nicorandil, a nitrate and potassium channel opener, is likely due to its action os a potassium channel opener, and not to its nitrate activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 11:05:24