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Titolo:
SIMULTANEOUS DETERMINATION OF THE BINARY-MIXTURES OF CEFSULODIN AND CLAVULANIC ACID BY USING FIRST-DERIVATIVE SPECTROPHOTOMETRY
Autore:
MURILLO JA; LEMUS JM; GARCIA LF;
Indirizzi:
UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL E-13071 CIUDAD REAL SPAIN
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 6, volume: 13, anno: 1995,
pagine: 769 - 776
SICI:
0731-7085(1995)13:6<769:SDOTBO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECTROMETRY;
Keywords:
DERIVATIVE SPECTROPHOTOMETRY; FIRST-DERIVATIVE SPECTROPHOTOMETRY; CEFSULODIN; CLAVULANIC ACID; SIMULTANEOUS DETERMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Murillo et al., "SIMULTANEOUS DETERMINATION OF THE BINARY-MIXTURES OF CEFSULODIN AND CLAVULANIC ACID BY USING FIRST-DERIVATIVE SPECTROPHOTOMETRY", Journal of pharmaceutical and biomedical analysis, 13(6), 1995, pp. 769-776

Abstract

Two-component mixtures of cefsulodin and clavulanic acid were analysed by a first-derivative spectrophotometric method using a zero-crossing technique of measurement. The relative ease offered by this derivative technique for the quantification of these drugs, with closely overlapping spectral bands, was clearly demonstrated. As the absorption band of clavulanic acid closely overlaps with that of cefsulodin, both direct and derivative spectrophotometric methods have been investigated and evaluated by an exhaustive statistical analysis of the experimental data. The first-derivative spectrophotometric method was found to bemore rapid, accurate and reproducible. The procedure does not requireany separation step. The calibration graphs were linear in the range 2.0-56.0 mu g ml(-1) for cefsulodin and 2.0-28.0 mu g ml(-1) for clavulanic acid. The lower detection limits of cefsulodin and clavulinic acid (P 0.05 level) were calculated to be 0.16 and 0.24 mu g ml(-1), respectively. Mixtures of cefsulodin and clavulanic acid in ratios of 1:4-7:2 were satisfactorily resolved. Both components were also determined in physiological solutions used to prepare intravenous infusions of these antibiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:11:37