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Titolo:
INHIBITION OF NEUTROPHIL OXIDATIVE-METABOLISM BY TRICHINOSIS PATIENT SERA - PARASITE ORIGIN OR HOST INDUCTION
Autore:
BRUSCHI F; CARULLI G; AZZARA A; MINNUCCI S;
Indirizzi:
UNIV PERUGIA,IST PATOL GEN I-06100 PERUGIA ITALY UNIV PISA,IST CLIN MED 1,UNITA EMATOL PISA ITALY
Titolo Testata:
Parasite immunology
fascicolo: 5, volume: 17, anno: 1995,
pagine: 253 - 260
SICI:
0141-9838(1995)17:5<253:IONOBT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; SPIRALIS; LARVAE; ACTIVATION; EXPRESSION; MECHANISM; INVITRO; ENZYMES; CELLS; MICE;
Keywords:
NEUTROPHILS; OXIDATIVE METABOLISM; TRICHINOSIS; SERA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
F. Bruschi et al., "INHIBITION OF NEUTROPHIL OXIDATIVE-METABOLISM BY TRICHINOSIS PATIENT SERA - PARASITE ORIGIN OR HOST INDUCTION", Parasite immunology, 17(5), 1995, pp. 253-260

Abstract

The presence of sera factors able to inhibit both neutrophil chemotaxis and phagocytosis was observed in all patients studied at two monthsfrom infection caused by Trichinella britovi and in most of them after one year. Human neutrophils with eosinophils are able to kill T. spiralis newborn larvae in an ADCC system and their major cytotoxic mechanism is oxidative metabolism products. We evaluated the effect of trichinellosis sera on neutrophil oxidative burst to determine if neutrophils are affected by circulating factors during infection. Cells were incubated with sera from trichinellosis patients. Basal or stimulated Superoxide Anion (SA) production and chemiluminescence in response to different stimulation (PMA, f-MLP, opsonized yeasts) of neutrophils incubated with trichinellosis sera were evaluated and compared with thoseof cells incubated with control sera. The results show that basal SA production was inhibited by 66% of sera and stimulated by 11%. On the contrary f-MLP stimulated production was significantly increased by 22% sera, and inhibited by none. Chemiluminescence in response to f-MLP or PMA was inhibited by 46 and 80% of sera, respectively. These results show that trichinellosis sera can modulate not only SA production but also other steps of the oxidative burst, irrespective of the stimulating agent, so suggesting that different neutrophil activation pathways are affected. Increased IL-2 levels observed in most of the sera didnot correlate with the inhibiting capacity of sera. The hypothesis ofa parasite origin of the inhibiting factors is discussed in the lightof host-parasite relationship.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:25:58