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Titolo:
IN-VITRO DRUG SUSCEPTIBILITY OF 29 ISOLATES OF GIARDIA-DUODENALIS FROM HUMANS AS ASSESSED BY AN ADHESION ASSAY
Autore:
FARBEY MD; REYNOLDSON JA; THOMPSON RCA;
Indirizzi:
MURDOCH UNIV,INST MOLEC GENET & ANIM DIS MURDOCH WA 6150 AUSTRALIA MURDOCH UNIV,INST MOLEC GENET & ANIM DIS MURDOCH WA 6150 AUSTRALIA MURDOCH UNIV,SCH VET STUDIES MURDOCH WA 6150 AUSTRALIA
Titolo Testata:
International journal for parasitology
fascicolo: 5, volume: 25, anno: 1995,
pagine: 593 - 599
SICI:
0020-7519(1995)25:5<593:IDSO2I>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIDRUG RESISTANCE; AUSTRALIAN ABORIGINES; INTESTINAL PARASITES; INVITRO; METRONIDAZOLE; BENZIMIDAZOLES; SENSITIVITY; TINIDAZOLE; CHILDREN; FURAZOLIDONE;
Keywords:
GIARDIA DUODENALIS; COMPARATIVE DRUG SUSCEPTIBILITY; METRONIDAZOLE; ALBENDAZOLE; CAUCASIANS; ABORIGINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Farbey et al., "IN-VITRO DRUG SUSCEPTIBILITY OF 29 ISOLATES OF GIARDIA-DUODENALIS FROM HUMANS AS ASSESSED BY AN ADHESION ASSAY", International journal for parasitology, 25(5), 1995, pp. 593-599

Abstract

Twelve isolates of Giardia duodenal is from Caucasian hosts in the Perth metropolitan area, along with 16 isolates from Aborigines in the north of Western Australia and the reference isolate P1C10 were examined for their in vitro drug sensitivity. Dose-response curves were constructed for each isolate for metronidazole, the most common clinically used antigiardial agent, as well as for the benzimidazole compound albendazole. Less than a 9-fold variation was found in the susceptibilityof the isolates to albendazole, while for metronidazole there was well over a 16,000-fold variation between the same group of isolates. In addition, it was found that isolates of Giardia obtained from Aboriginal hosts were significantly less sensitive to albendazole than those obtained from Caucasians. The results of this study have important implications for the continued use of metronidazole and the potential use of albendazole for the treatment of giardiasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 05:36:48