Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) PROMOTES THE TRANSLOCATION OF PROTEIN-KINASE-C (PKC) - REQUIREMENT OF VIABLE SEROTONIN NERVE-TERMINALS
Autore:
KRAMER HK; POBLETE JCP; AZMITIA EC;
Indirizzi:
NYU,DEPT BIOL,100 WASHINGTON SQ E,MAIN BLDG,ROOM 1009 NEW YORK NY 10003
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 680, anno: 1995,
pagine: 1 - 8
SICI:
0006-8993(1995)680:1-2<1:3(PTT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN SYNAPTOSOMES; 5-HT2 RECEPTORS; PARA-CHLOROAMPHETAMINE; CEREBRAL-CORTEX; NEURONAL DEATH; MDMA ECSTASY; BINDING-SITE; RELEASE; METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE;
Keywords:
SEROTONIN; SEROTONIN, RECEPTOR; CALCIUM; 2ND MESSENGER; RELEASE; DEGENERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H.K. Kramer et al., "3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) PROMOTES THE TRANSLOCATION OF PROTEIN-KINASE-C (PKC) - REQUIREMENT OF VIABLE SEROTONIN NERVE-TERMINALS", Brain research, 680(1-2), 1995, pp. 1-8

Abstract

The metabolic effects of the neurotoxic, ring-substituted amphetamine3,4-methylenedioxy-methamphetamine (MDMA or 'Ecstasy') were examined in vivo. In this study, we focused on the ability of MDMA to induce a translocation of the calcium and phospholipid-dependent protein kinaseC (PKC) from the cytosol to the cortical plasma membrane. Two injections of MDMA (20 mg/kg; 10 h apart; s.c.) increased the density of membrane bound PKC sites by 48.0% over saline treated animals without mediating a significant change in ligand ([H-3]phorbol 12,13 dibutyrate; [H-3]PDBu) affinity. Longer drug treatments (8 X 20 mg/kg) induced a lasting (up to 5 days post-treatment) increase in the density of membrane-bound PKC. Prior destruction of cortical 5-HT nerve terminals with p-chloroamphetamine (PCA) prevents this effect and suggests that viable5-HT uptake sites we essential for MDMA-induced PKC translocation. These results demonstrate that MDMA-induced PKC translocation Is mediated by viable cortical 5-HT nerve terminals, and that prolonged kinase activation may contribute to MDMA-induced serotonergic neurotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:14:54