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Titolo:
MICROSATELLITE INSTABILITY - NEW ASPECTS IN THE CARCINOGENESIS OF COLORECTAL-CARCINOMA
Autore:
RUSCHOFF J; BOCKER T; SCHLEGEL J; STUMM G; HOFSTAEDTER F;
Indirizzi:
UNIV REGENSBURG,INST PATHOL,FRANZ JOSEF STR ALLEE 11 D-93042 REGENSBURG GERMANY
Titolo Testata:
Virchows Archiv
fascicolo: 3, volume: 426, anno: 1995,
pagine: 215 - 222
SICI:
0945-6317(1995)426:3<215:MI-NAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOMIC INSTABILITY; NATURAL-HISTORY; MISMATCH REPAIR; CANCER; MUTATIONS; COLON;
Keywords:
COLORECTAL CARCINOMA; HEREDITARY NONPOLYPOSIS COLONIC CANCER; MICROSATELLITE INSTABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
J. Ruschoff et al., "MICROSATELLITE INSTABILITY - NEW ASPECTS IN THE CARCINOGENESIS OF COLORECTAL-CARCINOMA", Virchows Archiv, 426(3), 1995, pp. 215-222

Abstract

Very recently a new molecular mechanism in the tumorigenesis of colorectal carcinoma has been described which is closely linked to hereditary non-polyposis colonic cancer (HNPCC). Ubiquitous changes in the length of simple repetitive DNA sequences between constitutional and tumour DNA occur in about 90% of cases of HNPCC and in about 15% of cases of non-familial, sporadic colorectal carcinoma. Such microsatellite instabilities have been shown to be the phenotypical marker of mutationsin the human homologues of prokaryotic mismatch repair genes (MutS, MutL, MutH). These data provide crucial new tools in the detection of patients at high risk of developing colon cancer and other HNPCC-related carcinomas. In addition, these developments provide new insights into a new, presumably primary event in oncogenesis, i.e. the occurrence of mutations in genomic stability genes leading to an increased cellular mutation rate (''mutator phenotype'') and thus to cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:53:30