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Titolo:
IDENTIFICATION OF THE TS2 18-RECOGNIZED EPITOPE ON THE CD2 MOLECULE AS A TARGET FOR SUPPRESSION OF T-CELL CYTOKINE SYNTHESIS/
Autore:
SCHWARZ M; BOHUSLAV J; MAJDIC O; STOCKINGER H; KNAPP W; HOLTER W;
Indirizzi:
UNIV VIENNA,SANDOZ RES INST,VIRCC,INST IMMUNOL,BORSCHKEGASSE 8A A-1090 VIENNA AUSTRIA UNIV VIENNA,SANDOZ RES INST,VIRCC,INST IMMUNOL A-1090 VIENNA AUSTRIA ST ANNA CHILDRENS HOSP,CHILDRENS CANC RES INST A-1090 VIENNA AUSTRIA
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 154, anno: 1995,
pagine: 5813 - 5820
SICI:
0022-1767(1995)154:11<5813:IOTT1E>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LYMPHOCYTES-T; FUNCTION-ASSOCIATED ANTIGEN-3; LOW-AFFINITY LIGAND; MONOCLONAL-ANTIBODIES; CYTOPLASMIC DOMAIN; TYROSINE PHOSPHORYLATION; NEGATIVE SIGNAL; LFA-3 ANTIGENS; BINDING-SITES; E-RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Schwarz et al., "IDENTIFICATION OF THE TS2 18-RECOGNIZED EPITOPE ON THE CD2 MOLECULE AS A TARGET FOR SUPPRESSION OF T-CELL CYTOKINE SYNTHESIS/", The Journal of immunology, 154(11), 1995, pp. 5813-5820

Abstract

CD2 mAb can inhibit T cell activation, but the mechanisms involved are still unclear. In this study, we identify the mAb TS2/18, previouslyreported to bind to an epitope on the distal domain of the CD2 molecule at amino acids 87-99 (1), as a particularly potent inhibitor of T cell cytokine synthesis. Although TS2/18 is comitogenic with the CD2R mAb VIT13, this mAb combination does not induce the secretion of substantial amounts of cytokines. When added to T cells stimulated with the CD2 mAb pair OKT11-VIT13, TS2/18 efficiently blocks the induction of cytokine synthesis induced by that CD2 mAb pair, although it does not interfere with the binding of OKT11. In addition, TS2/18 inhibits the increase in protein tyrosine phosphorylation and the accumulation of phosphatidic acid induced by either OKT11-VIT13 or a cross-linked CD3 mAb. Finally, TS2/18 disrupts CD2 clusters induced by the CD2 mAb pair OKT11-VIT13. We conclude that TS2/18 blocks T cell cytokine synthesis by interfering with early signal transduction, possibly by impairing the formation of signal-transducing molecule complexes on the T cell surface. Together, these data identify the CD2 epitope recognized by the mAb TS2/18 as a candidate epitope for T cell-specific immunosuppressive ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:06:35