Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VASOACTIVE INTESTINAL POLYPEPTIDE AND OTHER PREPROVASOACTIVE INTESTINAL POLYPEPTIDE-DERIVED PEPTIDES IN THE FEMALE AND MALE GENITAL-TRACT -LOCALIZATION, BIOSYNTHESIS, AND FUNCTIONAL AND CLINICAL-SIGNIFICANCE
Autore:
OTTESEN B; FAHRENKRUG J;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT OBSTET & GYNECOL,KETTEGAARD ALLE 30 DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,BISPEBJERG HOSP,DEPT CLIN BIOCHEM COPENHAGEN DENMARK
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 5, volume: 172, anno: 1995,
pagine: 1615 - 1631
SICI:
0002-9378(1995)172:5<1615:VIPAOP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-BETA-HYDROXYLASE; VASCULAR SMOOTH-MUSCLE; MYOMETRIAL BLOOD-FLOW; PIG UTERINE ARTERY; MALE GENITOURINARY TRACT; NON-NORADRENERGIC AXONS; VIP-CONTAINING SYSTEM; RAT GRANULOSA-CELLS; SUBSTANCE-P; PENILE ERECTION;
Keywords:
REGULATORY PEPTIDES; PREPROVASOACTIVE INTESTINAL POLYPEPTIDE; PEPTIDE HISTIDINE METHIONINE; PEPTIDE HISTIDINE VALINE; REPRODUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
175
Recensione:
Indirizzi per estratti:
Citazione:
B. Ottesen e J. Fahrenkrug, "VASOACTIVE INTESTINAL POLYPEPTIDE AND OTHER PREPROVASOACTIVE INTESTINAL POLYPEPTIDE-DERIVED PEPTIDES IN THE FEMALE AND MALE GENITAL-TRACT -LOCALIZATION, BIOSYNTHESIS, AND FUNCTIONAL AND CLINICAL-SIGNIFICANCE", American journal of obstetrics and gynecology, 172(5), 1995, pp. 1615-1631

Abstract

Vasoactive intestinal polypeptide, a neuropeptide with wide distribution in the central and peripheral nervous system, has a broad spectrumof biologic actions. The demonstration of vasoactive intestinal polypeptide containing nerve fibers within the female and male genital tract 17 years ago indicated a putative role for this peptide in the localnervous control of reproductive functions. The genes encoding the preprovasoactive intestinal polypeptide precursor molecule and the vasoactive intestinal polypeptide receptor have been identified. The gene expression has been studied by the use of specific antibodies against the functional domains of the vasoactive intestinal polypeptide precursor and the biologic action elucidated by both in vivo and in vitro methods. Evidence has been provided to support vasoactive intestinal polypeptide as a neurotransmitter in several physiologic events in the genital tracts (i.e., blood flow and nonvascular smooth muscle relaxation). In the ovary vasoactive intestinal polypeptide seems to play an important role as regulator and/or modulator of folliculogenesis and steroidogenesis. In the male genital tract vasoactive intestinal polypeptide seems to participate in the control of erection. Vasoactive intestinal polypeptide has been suggested as a causative factor in some diseases of the genital organs (e.g., it may play a pathophysiologic role inmale impotence and the peptide is currently used in the treatment of this condition). Vasoactive intestinal polypeptide may be important for control of the low resistance in the fetomaternal vascular bed and is therefore a putative factor involved in the development of preeclampsia. The therapeutic potential of vasoactive intestinal polypeptide and future agonists and antagonists will be revealed by ongoing and forthcoming studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:15:41