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Titolo:
MATERNAL CARBOHYDRATE-METABOLISM AND ITS RELATIONSHIP TO FETAL GROWTHAND BODY-COMPOSITION
Autore:
CATALANO PM; DRAGO NM; AMINI SB;
Indirizzi:
CASE WESTERN RESERVE UNIV,METROHLTH MED CTR,DEPT REPROD BIOL,2500 METROHLTH DR CLEVELAND OH 44109 UNIV VERMONT,COLL MED,DEPT OBSTET & GYNECOL BURLINGTON VT 00000
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 5, volume: 172, anno: 1995,
pagine: 1464 - 1470
SICI:
0002-9378(1995)172:5<1464:MCAIRT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOLERANCE TEST VALUE; GLUCOSE-TOLERANCE; DIABETES-MELLITUS; INSULIN RESISTANCE; PREGNANCY; WOMEN; COMPLICATIONS;
Keywords:
NEONATAL BODY COMPOSITION; FETAL GROWTH; INSULIN SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Catalano et al., "MATERNAL CARBOHYDRATE-METABOLISM AND ITS RELATIONSHIP TO FETAL GROWTHAND BODY-COMPOSITION", American journal of obstetrics and gynecology, 172(5), 1995, pp. 1464-1470

Abstract

OBJECTIVE: Our purpose was to correlate maternal carbohydrate metabolism and parental morphometric measurements with neonatal birth weight,body composition, and placental weight. STUDY DESIGN: Sixteen singleton (six control and 10 abnormal glucose tolerance) infants had placental weight, birth weight, and estimates of body composition performed within 24 hours of birth. Independent variables considered were (1) maternal and paternal demographic and morphometric measures, (2) neonatalsex and gestational age, and (3) estimates of maternal carbohydrate metabolism, including basal hepatic glucose production, insulin response, and insulin sensitivity. All metabolic measurements were performed before conception and in early (12 to 14 weeks) and late (34 to 36 weeks) gestation. Best-fit stepwise regression analysis was used to relate the independent variables with placental weight, neonatal birth weight, fat-free mass, and fat mass. RESULTS: Insulin sensitivity in late gestation had the strongest correlation with placental weight (R(2) = 0.28), neonatal birth weight (R(2) = 0.28), and fat-free mass (R(2) = 0.33). In contrast, insulin sensitivity before conception had the bestcorrelation with neonatal fat mass (R(2) = 0.15). Including all significant independent variables in the model improved the correlations for placental weight (R(2) = 0.58), birth weight (R(2) = 0.48), fat-freemass (R(2) = 0.53), and fat mass (R(2) = 0,46), CONCLUSION: Maternal insulin sensitivity had stronger correlations with fetoplacental growth in comparison with maternal demographic or morphometric factors.

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Documento generato il 20/09/20 alle ore 19:39:30