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Titolo:
CHANGES IN GASTRIC FUNCTION AND HEALING OF CHRONIC GASTRIC-ULCERS IN AGED RATS
Autore:
TSUKIMI Y; OKABE S;
Indirizzi:
KYOTO PHARMACEUT UNIV,DEPT APPL PHARMACOL KYOTO 607 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 68, anno: 1995,
pagine: 103 - 110
SICI:
0021-5198(1995)68:1<103:CIGFAH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; TROPHIC ACTION; SERUM GASTRIN; INDOMETHACIN; SECRETION; STOMACH; PROSTAGLANDIN-E2; SOMATOSTATIN; STIMULATION; OMEPRAZOLE;
Keywords:
AGING; ACETIC ACID ULCER; GASTRIC FUNCTION; ULCER HEALING; ACID SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y. Tsukimi e S. Okabe, "CHANGES IN GASTRIC FUNCTION AND HEALING OF CHRONIC GASTRIC-ULCERS IN AGED RATS", Japanese Journal of Pharmacology, 68(1), 1995, pp. 103-110

Abstract

The present study was designed to determine the relationship between changes in gastric function caused by aging and the healing of gastriculcers. Male Fischer-344 rats (young, 2 months; aged, 24 - 26 months)were used. Gastric ulcers were induced by luminal application of an acetic acid solution (60%, 0.2 ml, 45 sec). The basal and histamine-stimulated gastric acid secretions in aged animals were significantly lower than those in young animals. However, the serum gastrin levels werealmost the same in the two groups. Gastric mucosal blood flow and mucosal cell proliferation were also decreased in aged animals. Gastric contractile activity induced by electrical vagal stimulation was almostthe same in the two groups, while the gastric relaxative response wassignificantly reduced in aged animals. The development and healing rate of gastric ulcers in aged animals were almost the same as those in young animals. Histologically, regeneration of the ulcerated mucosa was significantly reduced and tissue contraction occurred in aged animals, as compared to in young animals. We concluded that aging had littleor no influence on the development and healing rate of gastric ulcersin rats, but the quality of ulcer healing was quite different betweenyoung and aged animals, probably resulting from various gastric dysfunctions related to ulcer healing.

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Documento generato il 10/07/20 alle ore 02:42:49