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Titolo:
EFFECT OF ORAL CORTICOSTERONE ADMINISTRATION ON LOCOMOTOR DEVELOPMENTOF NEONATAL AND JUVENILE RATS
Autore:
PAVLOVSKATEGLIA G; STODULSKI G; SVENDSEN L; DALTON K; HAU J;
Indirizzi:
UNIV LONDON ROYAL COLL VET SURG,DEPT PATHOL & INFECT DIS,ANIM SCI & WELF LAB,ROYAL COLL ST LONDON NW1 0TU ENGLAND
Titolo Testata:
Experimental physiology
fascicolo: 3, volume: 80, anno: 1995,
pagine: 469 - 475
SICI:
0958-0670(1995)80:3<469:EOOCAO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN; GLUCOCORTICOIDS; DEPRESSION; PITUITARY; STEROIDS; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
G. Pavlovskateglia et al., "EFFECT OF ORAL CORTICOSTERONE ADMINISTRATION ON LOCOMOTOR DEVELOPMENTOF NEONATAL AND JUVENILE RATS", Experimental physiology, 80(3), 1995, pp. 469-475

Abstract

In order to simulate the elevated corticosteroid levels to which offspring of stressed women may be subjected, rat pups were treated daily with two levels of oral corticosterone from the 2nd to the 15th postnatal day. The rat pups were subjected to swimming tests from their 8th postnatal day to examine their neuromuscular development and learning abilities. The locomotor performance of corticosterone-treated groups was similar to that of controls but its development was delayed, whichdemonstrates that even relatively low levels of corticosterone have asignificant negative influence on the maturation and learning abilityof neonatal rat pups. This indicates that the glucocorticoid levels to which suckling neonates (for example, children of women suffering from stress) might be exposed could modify the complex integrated neuromuscular adaptive mechanisms involved in normal locomotor development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:49:29