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Titolo:
MULTIPLE SPECIFIC CHROMOSOMAL ALTERATIONS IN A RAT ASCITIC HISTIOCYTOMA AK-5
Autore:
ROY JK; MAJUMDAR KC; PATHAK S; KHAR A;
Indirizzi:
CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL HOUSTON TX 77030
Titolo Testata:
Anticancer research
fascicolo: 2, volume: 15, anno: 1995,
pagine: 289 - 294
SICI:
0250-7005(1995)15:2<289:MSCAIA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; NORVEGICUS; CANCER; GENES;
Keywords:
HISTIOCYTOMA; MARKER CHROMOSOMES; KARYOTYPES; HYPODIPLOID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Roy et al., "MULTIPLE SPECIFIC CHROMOSOMAL ALTERATIONS IN A RAT ASCITIC HISTIOCYTOMA AK-5", Anticancer research, 15(2), 1995, pp. 289-294

Abstract

In the rat ascitic histiocytoma, AK-5, chromosome numbers vary between 33 and 41 with a peak at 40 chromosomes. None of the metaphase spreads showed double minute chromosomes. The karyotype of this tumor was characterized;ecl by hypodiploid chromosome constitution. Giemsa banding analysis revealed 12 clonal marker chromosomes (M1-M12). Tentative identification of these markers M1 = ins(1a); M2 = t(5;?); M3 = t(8;10); M4 = t(8;?); M5 = t(10;X); M6 - t(l5;?); M7 = t(5;6); M8 = del(13p);M9-M12 = unidentified. M3 being a large near metacentric chromosome serves as a characteristic marker for this tumor: All marker chromosomes except M2 and M4 were present in single copy per cell. In some metaphases M2 was present in 2 copies while M4 was present in 2 ol 3 copiesper cell. The total cell cycle duration of AK-5 cells was 15.5 h and the different phases, G1, S, G2+M were estimated as 1.2, 12.2, and 2 h, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:16:46