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Titolo:
PRELIMINARY-STUDY OF MAGNETIC-RESONANCE-IMAGING CHARACTERISTICS IN 8-YEAR-OLDS TO 16-YEAR-OLDS WITH MANIA
Autore:
BOTTERON KN; VANNIER MW; GELLER B; TODD RD; LEE BCP;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,1 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL ST LOUIS MO 63110
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 6, volume: 34, anno: 1995,
pagine: 742 - 749
SICI:
0890-8567(1995)34:6<742:POMCI8>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; GLOBAL ASSESSMENT SCALE; ABNORMALITIES; BRAIN; DEPRESSION; CHILDREN; SCHIZOPHRENIA; LESIONS; CORTEX; RATES;
Keywords:
CHILD; ADOLESCENT; MAGNETIC RESONANCE IMAGING; BRAIN; NEUROIMAGING; BIPOLAR; BRAIN VOLUME; LATERAL VENTRICLES; PETALIA; NEURODEVELOPMENT; NEUROMORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
K.N. Botteron et al., "PRELIMINARY-STUDY OF MAGNETIC-RESONANCE-IMAGING CHARACTERISTICS IN 8-YEAR-OLDS TO 16-YEAR-OLDS WITH MANIA", Journal of the American Academy of Child and Adolescent Psychiatry, 34(6), 1995, pp. 742-749

Abstract

Objective: To examine magnetic resonance imaging (MRI) characteristics in children and adolescents with mania according to DSM-III-R criteria. Method: A convenience sample of consecutively referred 8- to 16-year-old manic (n = 10) and normal (n = 5) subjects were assessed using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present Episode Version, the Children's Global Assessment Scale, and the Family History-Research Diagnostic Criteria. MRI scans were obtained from unsedated subjects using a 1.5 T MR scanner to acquireT-1-weighted coronal and sagittal images and T-2-weighted axial images. Images were assessed by blind clinical interpretation, ratings of T-2-weighted deep white matter hyperintensities and petalia, and computer-assisted volumetric analysis of ventricular and cerebral volumes. Results: Eight of 10 manic subjects and all 5 controls completed the scans. Scans of 4 manic subjects and 1 control subject showed ventricular or white matter abnormalities by clinical interpretation. Significant findings were positive correlations between increasing age and both right and left ventricular volumes. Two of the 8 manic subjects and nocontrols had confluent subcortical hyperintensities. Conclusions: MRIbrain scanning was feasible in 8- to 16-year-olds. Preliminary findings from clinical interpretations and structured ratings suggest structural differences between young manic and normal subjects. Investigations of larger samples are needed to better characterize the differences.

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Documento generato il 11/07/20 alle ore 21:03:53