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Titolo:
NEUROFIBROMATOSIS TYPE-1 - PATHOLOGICAL SUBSTRATE OF HIGH-SIGNAL-INTENSITY FOCI IN THE BRAIN
Autore:
DIPAOLO DP; ZIMMERMAN RA; RORKE LB; ZACKAI EF; BILANIUK LT; YACHNIS AT;
Indirizzi:
THOMAS JEFFERSON UNIV HOSP,DEPT RADIOL PHILADELPHIA PA 00000 CHILDRENS HOSP,DEPT NEUROPATHOL PHILADELPHIA PA 19104 CHILDRENS HOSP,DEPT GENET PHILADELPHIA PA 19104 CHILDRENS HOSP,DEPT RADIOL PHILADELPHIA PA 19104
Titolo Testata:
Radiology
fascicolo: 3, volume: 195, anno: 1995,
pagine: 721 - 724
SICI:
0033-8419(1995)195:3<721:NT-PSO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MR FINDINGS; LESIONS; IMAGES;
Keywords:
BRAIN NEOPLASMS, MR; BASAL GANGLIA, DISEASES; BRAIN, WHITE MATTER; NEUROFIBROMATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Dipaolo et al., "NEUROFIBROMATOSIS TYPE-1 - PATHOLOGICAL SUBSTRATE OF HIGH-SIGNAL-INTENSITY FOCI IN THE BRAIN", Radiology, 195(3), 1995, pp. 721-724

Abstract

PURPOSE: To investigate a correlation between pathologic and radiologic findings with regard to the characteristic high-signal-intensity foci seen on long repetition time (TR) magnetic resonance (MR) images ofthe brain in patients with neurofibromatosis type 1 (NF-1). MATERIALSAND METHODS: Three girls with NF-1 and abnormal hyperintensities on long TR images of the brain underwent pathologic examination at autopsy. RESULTS: Two 10-year-old girls had classic, focal hyperintensities in the internal capsules and globus pallidus regions, which have been associated with NF-1. The third patient, a neonate, had diffuse hyperintensity of the supratentorial and infratentorial white matter on T2-weighted MR images. Findings at histopathologic examination revealed spongiotic change in the tissue sections that correspond to the high-signal-intensity foci demonstrated on T2-weighted images. CONCLUSION: Hyperintense foci seen on T2-weighted MR images appear to correspond to pathologic findings of areas of vacuolar or spongiotic change. The resultant fluid-filled vacuoles explain the occurrence of high signal intensity demonstrated on T2-weighted images.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 00:18:50