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Titolo:
EXPRESSION AND INDUCIBILITY OF CYTOCHROME-P450-3A9 (CYP3A9) AND OTHERMEMBERS OF THE CYP3A-SUBFAMILY IN RAT-LIVER
Autore:
MAHNKE Z; STROTKAMP D; ROOS PH; HANSTEIN WG; CHABOT GG; NEF P;
Indirizzi:
RUHR UNIV BOCHUM,INST PHYSIOL CHEM D-44780 BOCHUM GERMANY RUHR UNIV BOCHUM,INST PHYSIOL CHEM D-44780 BOCHUM GERMANY INST GUSTAVE ROUSSY,CNRS,URA 147,PHARMACOTOXICOL & PHARMACOGENET LAB F-94805 VILLEJUIF FRANCE UNIV GENEVA,DEPT BIOCHEM CH-1211 GENEVA 4 SWITZERLAND
Titolo Testata:
Archives of biochemistry and biophysics
fascicolo: 1, volume: 337, anno: 1997,
pagine: 62 - 68
SICI:
0003-9861(1997)337:1<62:EAIOC(>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNAS; COMPLETE CDNA; GENE FAMILY; TESTOSTERONE; CLONING; 6-BETA-HYDROXYLASE; MICROSOMES; ISOZYMES; SEQUENCE; METABOLISM;
Keywords:
RAT CYP3A TRANSCRIPTION; RT-PCR; ADULT SPECIFIC GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Z. Mahnke et al., "EXPRESSION AND INDUCIBILITY OF CYTOCHROME-P450-3A9 (CYP3A9) AND OTHERMEMBERS OF THE CYP3A-SUBFAMILY IN RAT-LIVER", Archives of biochemistry and biophysics, 337(1), 1997, pp. 62-68

Abstract

Quantitative reverse-transcriptase polymerase chain reaction was usedto determine the content of mRNA derived from four CYP3A genes (CYP3A2, CYP3A9, CYP3A18, and CYP3A23) in rat liver. CYP3A2 and CYP3A9 gene expression was age- and sex-dependent, whereas CYP3A18 and CYP3A23 mRNA were observed before and after puberty at fairly constant levels that were about 20% higher in males than in females. CYP3A9 mRNA was detected only in adult rats, with a nearly twofold higher expression in females. CYP3A9 induction was different from other CYP3A isoenzymes, since phenobarbital was a more effective inducer than dexamethasone and clotrimazole. The results presented for CYP3A23 are those anticipated for CYP3A1, which may be an allelic variant of CYP3A23 not detected in these experiments. These data show that rat CYP3A genes are variably expressed depending on age, sex, or inducer type. (C) 1997 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:21:28