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Titolo:
SKELETAL-MUSCLE GLUT4 PROTEIN-CONCENTRATION AND AGING IN HUMANS
Autore:
HOUMARD JA; WEIDNER MD; DOLAN PL; LEGGETTFRAZIER N; GAVIGAN KE; RICKEY MS; TYNDALL GL; ZHEN DH; ALSHAMI A; DOHM GL;
Indirizzi:
E CAROLINA UNIV,SCH HLTH & HUMAN PERFORMANCE,HUMAN PERFORMANCE LAB,371 SPORTS MED BLDG GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT BIOCHEM GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT MED GREENVILLE NC 27858
Titolo Testata:
Diabetes
fascicolo: 5, volume: 44, anno: 1995,
pagine: 555 - 560
SICI:
0012-1797(1995)44:5<555:SGPAAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TRANSPORTER GLUT4; DEPENDENT DIABETIC-PATIENTS; INSULIN-RESISTANT PATIENTS; BETA-CELL FUNCTION; MIDDLE-AGED MEN; ALTERED EXPRESSION; WHOLE-BODY; EXERCISE; OBESITY; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Houmard et al., "SKELETAL-MUSCLE GLUT4 PROTEIN-CONCENTRATION AND AGING IN HUMANS", Diabetes, 44(5), 1995, pp. 555-560

Abstract

The insulin resistance of aging has been attributed to a postreceptordefect in skeletal muscle, The present study examined whether a reduction in the concentration of the insulin-stimulated glucose transporter (GLUT4) in skeletal muscle was associated with advancing age in men (n = 55) and women (n = 29), Insulin sensitivity (minimal model) was negatively associated (P < 0.001) with age (range, 18-80 years) in men (r = -0.44) and women (r = -0.58). GLUT4 protein concentration in the vastus lateralis was also negatively associated (P < 0.05) with age (men, r = -0.28; women, r = -0.51), There was no relation (P > 0.15) between GLUT4 content in the gastrocnemius and age, GLUT4 concentration in the vastus lateralis was positively associated (P < 0.01) with insulin sensitivity in both sexes (r = 0.42); this relationship persisted in the men after adjusting for overall adiposity, regional adiposity, and cardiorespiratory fitness. These findings suggest that a decrement in GLUT4 protein concentration in skeletal muscle may at least partially contribute to the insulin resistance of aging in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:44:14