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Titolo:
USING HITCHHIKING GENES TO STUDY ADAPTATION AND DIVERGENCE DURING SPECIATION WITHIN THE DROSOPHILA-MELANOGASTER SPECIES COMPLEX
Autore:
HILTON H; KLIMAN RM; HEY J;
Indirizzi:
RADFORD UNIV,DEPT BIOL RADFORD VA 24124 RUTGERS STATE UNIV,NELSON LABS PISCATAWAY NJ 08855
Titolo Testata:
Evolution
fascicolo: 6, volume: 48, anno: 1994,
pagine: 1900 - 1913
SICI:
0014-3820(1994)48:6<1900:UHGTSA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE REGION; DNA-SEQUENCE VARIATION; ALCOHOL-DEHYDROGENASE; CENTROMERIC REGION; X-CHROMOSOME; ANANASSAE POPULATIONS; NATURAL-POPULATIONS; MOLECULAR EVOLUTION; SYNONYMOUS CODONS; POLYMORPHISM;
Keywords:
ASENSE; CUBITUS INTERRUPTUS DOMINANT; PHYLOGENY; SPECIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
H. Hilton et al., "USING HITCHHIKING GENES TO STUDY ADAPTATION AND DIVERGENCE DURING SPECIATION WITHIN THE DROSOPHILA-MELANOGASTER SPECIES COMPLEX", Evolution, 48(6), 1994, pp. 1900-1913

Abstract

Several studies of intraspecific and interspecific DNA sequence variation from Drosophila loci have revealed a pattern of low intraspecificvariation from genomic regions of low recombination. The mechanisms consistently invoked to explain these patterns are the selective sweep of advantageous mutations together with genetic hitchhiking of linked loci. To examine the effect of selective sweeps on genetic divergence during speciation, we studied two loci in different genomic regions thought to be subject to selective sweeps. We obtained DNA sequences from 1.1-kb pair portions of the fourth chromosome locus cubitus interruptus Dominant (ci(D)) and from the asense locus near the telomere of the X chromosome. At ci(D), we found very low variation among multiple lines of Drosophila mauritiana and D. sechellia. This Ending is consistent with an earlier report of very low variation in D, melanogaster and D. simulans at ci(D) and supports the conclusion of selective sweepsand genetic hitchhiking on the nonrecombining fourth chromosome. The pattern of variation found at asense suggests that a selective sweep has occurred recently at the tip of the X chromosome in D. simulans, but not in D. melanogaster or D. mauritiana. The data from ci(D) and asense are compared with data from three X chromosome loci (period, zeste, and yolk protein 2) that experience normal levels of recombination. By examining estimated genealogies and the rates at which different classes of mutations have accumulated, we conclude that selective sweepsare common occurrences on the fourth chromosome but less common near the tip of the X chromosome. An interesting pattern of low variation at ci(D) among D. simulans, D. mauritiana, and D. sechellia suggests that a selective sweep may have occurred among these forms even after divergence into separate species had begun.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:32:43