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Titolo:
SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF THE GERBIL AFTER TRANSIENT ISCHEMIA
Autore:
TSUBOKAWA H; OGURO K; MASUZAWA T; KAWAI N;
Indirizzi:
JICHI MED SCH,DEPT PHYSIOL MINAMI KAWACHI TOCHIGI 32904 JAPAN JICHI MED SCH,DEPT NEUROSURG MINAMI KAWACHI TOCHIGI 32904 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 191, anno: 1995,
pagine: 95 - 98
SICI:
0304-3940(1995)191:1-2<95:SEPCIH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DAMAGE; DEATH;
Keywords:
CEREBRAL ISCHEMIA; GERBIL; HIPPOCAMPAL SLICE, PATCH CLAMP; SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENTS; QUANTAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Tsubokawa et al., "SPONTANEOUS EXCITATORY POSTSYNAPTIC CURRENTS IN HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF THE GERBIL AFTER TRANSIENT ISCHEMIA", Neuroscience letters, 191(1-2), 1995, pp. 95-98

Abstract

The changes in the spontaneous excitatory postsynaptic currents (sEPSCs) after transient cerebral ischemia were studied using whole-cell recording from CA1 pyramidal neurons in the gerbil. In neurons recorded 1-2 days after ischemia, sEPSCs had a slowed time course with the decay time constant fitted by a single exponential and it progressively increased after ischemia. Frequency and amplitude distribution of sEPSCsin ischemic neurons were not significantly different from those in the control neurons. The results support the view that abnormal non-N-methyl-D-aspartic acid currents originate at the degenerated postsynaptic site, unrelated to the presynaptic releasing mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 02:53:50