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Titolo:
HUMAN AND MOUSE DOPAMINE TRANSPORTER GENES - CONSERVATION OF 5'-FLANKING SEQUENCE ELEMENTS AND GENE STRUCTURES
Autore:
DONOVAN DM; VANDENBERGH DJ; PERRY MP; BIRD GS; INGERSOLL R; NANTHAKUMAR E; UHL GR;
Indirizzi:
MOLEC NEUROBIOL BRANCH,BOX 5180 BALTIMORE MD 21224 MOLEC NEUROBIOL BRANCH BALTIMORE MD 21224 NIDA,ADDICT RES CTR,DIV INTRAMURAL RES,OFF DIRECTOR BALTIMORE MD 21224 GENET CORE FACIL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI BALTIMORE MD 21205
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 30, anno: 1995,
pagine: 327 - 335
SICI:
0169-328X(1995)30:2<327:HAMDTG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC EXPRESSION; NEUROTRANSMITTER TRANSPORTERS; TYROSINE-HYDROXYLASE; CLONING; COCAINE; DNA; TRANSCRIPTION; DISPLAYS; PROTEIN; REGION;
Keywords:
TRANSPORTER; PROMOTER; GENE; PARKINSONS DISEASE; COCAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Donovan et al., "HUMAN AND MOUSE DOPAMINE TRANSPORTER GENES - CONSERVATION OF 5'-FLANKING SEQUENCE ELEMENTS AND GENE STRUCTURES", Molecular brain research, 30(2), 1995, pp. 327-335

Abstract

Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of Parkinsonism-inducing neurotoxins, make understanding of the DAT gene of interest. Isolation and characterization of the human and mouse DAT genes has allowed elucidation of similarities between each and other members of this transporter gene family. Sequences 5' to transcriptional start sites contain G-C rich, TATA-less, CAAT-less regions with striking conservation between human and mouse gene flanking regions. These studies suggest sequence elements that are candidates to contribute to the dopamine transporter's dopaminergic cell-specific expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:09:50