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Titolo:
THE EFFECT OF TROPISETRON INJECTED INTO THE NUCLEUS-ACCUMBENS-SEPTI ON ETHANOL-CONSUMPTION IN RATS
Autore:
JANKOWSKA E; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND
Titolo Testata:
Alcohol
fascicolo: 3, volume: 12, anno: 1995,
pagine: 195 - 198
SICI:
0741-8329(1995)12:3<195:TEOTII>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT(3) RECEPTOR ANTAGONISTS; DOPAMINE RELEASE; EXTRACELLULAR DOPAMINE; BRAIN; STIMULATION; ACTIVATION; BINDING; LINE;
Keywords:
ETHANOL INTAKE; ETHANOL PREFERENCE; 5-HT3 RECEPTOR; 5-HT3 ANTAGONIST; ICS 205-930; TROPISETRON; NUCLEUS ACCUMBENS SEPTI; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E. Jankowska e W. Kostowski, "THE EFFECT OF TROPISETRON INJECTED INTO THE NUCLEUS-ACCUMBENS-SEPTI ON ETHANOL-CONSUMPTION IN RATS", Alcohol, 12(3), 1995, pp. 195-198

Abstract

Earlier studies have shown that 5-HT3 antagonists possess properties of reducing ethanol (EtOH) preference and intake in EtOH high-preferring rats. In this study we examined the effect of tropisetron (ICS 205-930) microinjection (1 and 10 ng) into the nucleus accumbens septi (NAS) on EtOH drinking in a scheduled access to EtOH paradigm. Control rats received vehicle only. Tropisetron, when injected bilaterally into the NAS, significantly reduced EtOH intake in EtOH high-preferring animals. It is concluded that 5-HT3 antagonists might exert their antipreference activity by influencing the receptors within the NAS and that 5-HT3 receptors might play an important role in reinforcing propertiesof EtOH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:36:09