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Titolo:
SLEEP-DEPRIVATION AND SPIKE-WAVE DISCHARGES IN EPILEPTIC RATS
Autore:
DRINKENBURG WHIM; COENEN AML; VOSSEN JMH; VANLUIJTELAAR ELJM;
Indirizzi:
UNIV NIJMEGEN,DEPT PSYCHOL,NICI,POB 9104 6500 HE NIJMEGEN NETHERLANDS
Titolo Testata:
Sleep
fascicolo: 4, volume: 18, anno: 1995,
pagine: 252 - 256
SICI:
0161-8105(1995)18:4<252:SASDIE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSENCE EPILEPSY; REM-SLEEP; EEG; STATES; STRAIN;
Keywords:
EPILEPSY; SLEEP DEPRIVATION; SLEEP-WAKE STATES; SPIKE-WAVE DISCHARGES; WAG/RIJ RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
W.H.I.M. Drinkenburg et al., "SLEEP-DEPRIVATION AND SPIKE-WAVE DISCHARGES IN EPILEPTIC RATS", Sleep, 18(4), 1995, pp. 252-256

Abstract

The effects of sleep deprivation were studied on the occurrence of spike-wave discharges in the electroencephalogram of rats of the epileptic WAG/Rij strain, a model for absence epilepsy. This was done before,during and after a period of 12 hours of near total sleep deprivation. A substantial increase in the number of spike-wave discharges was found during the first 4 hours of the deprivation period, whereas in thefollowing deprivation hours epileptic activity returned to baseline values. Immediately after termination of deprivation, a decrease in thenumber of spike-wave discharges parallelled a rebound of rapid eye movement (REM) sleep and deep non-REM sleep. An initial increase in epileptic activity has also been reported during sleep deprivation of humans. This initial increase as well as the epileptogenic effects during the course of the sleep deprivation and during the recovery period after sleep deprivation can be interpreted in terms of changes in sleep-wake states. Although the epilepsy-provoking mechanisms are not yet understood, an explanation is suggested based on changes of transitions between sleep wake states and shifts in level of synchronization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 22:37:28