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Titolo:
BCLX REGULATES THE SURVIVAL OF DOUBLE-POSITIVE THYMOCYTES
Autore:
MA A; PENA JC; CHANG B; MARGOSIAN E; DAVIDSON L; ALT FW; THOMPSON CB;
Indirizzi:
HARVARD UNIV,CHILDRENS HOSP,SCH MED,HOWARD HUGHES MED INST BOSTON MA 02115 HARVARD UNIV,CHILDRENS HOSP,SCH MED,HOWARD HUGHES MED INST BOSTON MA 02115 HARVARD UNIV,SCH MED,CTR BLOOD RES,DEPT GENET BOSTON MA 02115 UNIV CHICAGO,HOWARD HUGHES MED INST,COMM IMMUNOL CHICAGO IL 60637 UNIV CHICAGO,DEPT MED,GWEN KNAPP CTR LUPUS & IMMUNOL RES CHICAGO IL 60637 UNIV CHICAGO,DEPT MOLEC GENET & CELL BIOL CHICAGO IL 60637
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 11, volume: 92, anno: 1995,
pagine: 4763 - 4767
SICI:
0027-8424(1995)92:11<4763:BRTSOD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOPTOTIC CELL-DEATH; FOLLICULAR LYMPHOMA; NEGATIVE SELECTION; T-CELLS; GENE; MICE; LYMPHOCYTES; RECEPTOR; PROTEIN; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Ma et al., "BCLX REGULATES THE SURVIVAL OF DOUBLE-POSITIVE THYMOCYTES", Proceedings of the National Academy of Sciences of the United Statesof America, 92(11), 1995, pp. 4763-4767

Abstract

The bclx gene has been shown to regulate programmed cell death in vitro. We now show that Bclx expression increases dramatically when T cells differentiate from CD4(-) CD8(-) (double negative) thymocytes to CD4(+) CD8(+) [double positive (DP)] thymocytes, In contrast single-positive (SP) thymocytes express negligible amounts of Bclx protein. This expression pattern contrasts with that of Bcl2, which is present in double-negative thymocytes, downregulated in DP thymocytes, and reinduced upon maturation to SP thymocytes. Elimination of Bclx by gene targeting dramatically shortens the survival of DP thymocytes but not the survival of SP thymocytes or peripheral SP T cells, These data suggest that the induction of Bclx during thymic maturation plays a critical role in regulating the length of time DP thymocytes survive in the absence of selection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:32:50