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Titolo:
ECTOPIC EXPRESSION OF THE AGOUTI GENE IN TRANSGENIC MICE CAUSES OBESITY, FEATURES OF TYPE-II DIABETES, AND YELLOW FUR
Autore:
KLEBIG ML; WILKINSON JE; GEISLER JG; WOYCHIK RP;
Indirizzi:
OAK RIDGE NATL LAB,DIV BIOL,POB 2009 OAK RIDGE TN 37831 OAK RIDGE NATL LAB,DIV BIOL OAK RIDGE TN 37831 UNIV TENNESSEE,COLL VET MED,DEPT PATHOBIOL KNOXVILLE TN 37916 UNIV TENNESSEE,GRAD SCH BIOMED SCI OAK RIDGE TN 37831
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 11, volume: 92, anno: 1995,
pagine: 4728 - 4732
SICI:
0027-8424(1995)92:11<4728:EEOTAG>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY PEPTIDES; AVY/A; INSULIN; CLONING; PROTEIN; LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Klebig et al., "ECTOPIC EXPRESSION OF THE AGOUTI GENE IN TRANSGENIC MICE CAUSES OBESITY, FEATURES OF TYPE-II DIABETES, AND YELLOW FUR", Proceedings of the National Academy of Sciences of the United Statesof America, 92(11), 1995, pp. 4728-4732

Abstract

Mice that carry the lethal yellow (A(y)) or viable yellow (A(vy)) mutation, two dominant mutations of the agouti (a) gene in mouse chromosome 2, exhibit a phenotype that includes yellow fur, marked obesity, a form of type II diabetes associated with insulin resistance, and an increased susceptibility to tumor development, Molecular analyses of these and several other dominant ''obese yellow'' a-locus mutations suggested that ectopic expression of the normal agouti protein gives rise to this complex pleiotropic phenotype, We have now tested this hypothesis directly by generating transgenic mice that ectopically express an agouti cDNA clone encoding the normal agouti protein in all tissues examined. Transgenic mice of both sexes have yellow fur, become obese, and develop hyperinsulinemia. In addition, male transgenic mice develophyperglycemia by 12-20 weeks of age, These results demonstrate conclusively that the ectopic agouti expression is responsible for most, if not all, of the phenotypic traits of the dominant, obese yellow mutants.

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Documento generato il 29/11/20 alle ore 05:15:03