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Titolo:
LIVER PERFUSION STUDIED WITH ULTRAFAST CT
Autore:
BLOMLEY MJK; COULDEN R; DAWSON P; KORMANO M; DONLAN P; BUFKIN C; LIPTON MJ;
Indirizzi:
HAMMERSMITH HOSP,DEPT RADIOL,DU CANE RD LONDON W12 ENGLAND UNIV CHICAGO HOSP,DEPT RADIOL CHICAGO IL 00000
Titolo Testata:
Journal of computer assisted tomography
fascicolo: 3, volume: 19, anno: 1995,
pagine: 424 - 433
SICI:
0363-8715(1995)19:3<424:LPSWUC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; COMPUTED-TOMOGRAPHY; RADIONUCLIDE ANGIOGRAPHY; DYNAMIC CT; VALIDATION; FRACTION;
Keywords:
COMPUTED TOMOGRAPHY, TECHNIQUES; LIVER, DISEASES; VEINS, HEPATIC; VEINS, PORTAL; PERFUSION STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.J.K. Blomley et al., "LIVER PERFUSION STUDIED WITH ULTRAFAST CT", Journal of computer assisted tomography, 19(3), 1995, pp. 424-433

Abstract

Objective: Our goal was to quantify absolute hepatic arterial and portal venous perfusion noninvasively in patients with and without liver disease using ultrafast CT. Materials and Methods: A single slice through the porta hepatis was repeatedly scanned after bolus injection of 25 ml of iohexol 300 mg I/ml, followed by a 25 ml saline ''chaser'' intravenously at 10 ml/s. Thirty-nine controls, 7 cirrhotic patients, and 5 patients with known metastases on the slice plane were studied; hepatic arterial perfusion was determined in 41 patients and portal venous perfusion in 24. Time-attenuation curves from regions of interest drawn over the liver, spleen, aorta, and portal vein were analysed. Hepatic arterial perfusion was calculated by dividing the peak gradient of the liver time-attenuation curve prior to the time of peak splenic attenuation by the peak aortic CT number increase. Splenic perfusion was calculated by dividing the peak gradient of the splenic time-attenuation curve by the peak aortic CT number increase. Portal perfusion wasderived by scaling the splenic time-attenuation curve by the ratio ofhepatic arterial/splenic perfusion. This scaled curve was subtracted from the liver time-attenuation curve to give a portal curve, The peakup-slope of this curve was divided by the peak rise in splenic or portal vein density. Results: Hepatic arterial perfusion averaged 0.,19 ml/min/ml (n = 31) in controls and was raised in cirrhosis to 0.25 ml/min/ml(n = 6) and metastases 0.43 ml/min/ml(n = 4). Portal venous perfusion was 0.93 ml/min/ml (n = 19) in controls and 0.43 ml/min/ml (n = 4) in cirrhosis, Reproducibility has been confirmed. Conclusion: Dynamic ultrafast CT shows potential in quantifying arterial and portal hepatic perfusion. The technique may be adaptable to dynamic bolus MRI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:06:13