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Titolo:
DENDRITIC CELL LOSS FROM NONLYMPHOID TISSUES AFTER SYSTEMIC ADMINISTRATION OF LIPOPOLYSACCHARIDE, TUMOR-NECROSIS-FACTOR, AND INTERLEUKIN-1
Autore:
ROAKE JA; RAO AS; MORRIS PJ; LARSEN CP; HANKINS DF; AUSTYN JM;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND
Titolo Testata:
The Journal of experimental medicine
fascicolo: 6, volume: 181, anno: 1995,
pagine: 2237 - 2247
SICI:
0022-1007(1995)181:6<2237:DCLFNT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-ALPHA; MONOCLONAL-ANTIBODY; SPECIES SPECIFICITY; LANGERHANS CELLS; FACTOR RECEPTORS; EXPRESSION; MIGRATION; MICE; LEUKOCYTES; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Roake et al., "DENDRITIC CELL LOSS FROM NONLYMPHOID TISSUES AFTER SYSTEMIC ADMINISTRATION OF LIPOPOLYSACCHARIDE, TUMOR-NECROSIS-FACTOR, AND INTERLEUKIN-1", The Journal of experimental medicine, 181(6), 1995, pp. 2237-2247

Abstract

Dendritic cells (DC) in nonlymphoid organs can internalize and process foreign antigens before migrating to secondary lymphoid tissues to initiate primary immune responses. However, there is little informationon which stimuli promote migration of DC from the tissues. Systemic administration of lipopolysaccharide (LPS), which induces in vivo production of cytokines, led to a reduction in the numbers of major histocompatibility complex class II-positive (Ia(+)) leukocytes in mouse hearts and kidneys: >95% of DC were depleted 1-3 d after injection of 50 mu g LPS. Several lines of evidence indicated that this response was due to migration of DC rather than loss of Ia expression or cytotoxic effects. In skin of treated mice, the number of Ia(+) epidermal Langerhans' cells (LC) was reduced, and ''cords'' of Ia(+) leukocytes became evident in the dermis. The latter cells expressed little NLDC145 and may have originated from recruited or resident DC progenitors. Systemic administration of recombinant tumor necrosis factor (rhTNF)-alpha resulted in a decrease in numbers of Ia(+) cells in heart and kidney and of epidermal LC, and it also induced dermal cords. Administration of a rh-interleukin (IL)-1 resulted in a decrease in Ia(+) cells only in renal medulla, appeared to activate a subset of epidermal LC, and induced dermal cords. Similar microgram doses of rhIL-2 had no obvious effect. Treatment with a neutralizing anti-TNF antiserum before LPS administration inhibited the depletion of LC from skin but not from heart or kidney. Therefore, TNF-alpha and IL-1 alpha may promote DC migration from nonlymphoid tissues and may have differential effects on differentDC populations, but it is unclear whether they act on DC directly or indirectly (e.g., via other cytokines).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:26:07