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Titolo:
DESFERRIOXAMINE INHIBITION OF THE HYDROXYL RADICAL-LIKE REACTIVITY OFPEROXYNITRITE - ROLE OF THE HYDROXAMIC GROUPS
Autore:
DENICOLA A; SOUZA JM; GATTI RM; AUGUSTO O; RADI R;
Indirizzi:
UNIV REPUBL MONTEVIDEO,FAC MED,DEPT BIOQUIM,AV GRAL FLORES 2125 MONTEVIDEO 11800 URUGUAY UNIV REPUBL MONTEVIDEO,FAC MED,DEPT BIOQUIM MONTEVIDEO 11800 URUGUAY UNIV REPUBL MONTEVIDEO,FAC CIENCIAS,DEPT PHYS BIOCHEM MONTEVIDEO URUGUAY UNIV SAO PAULO,INST QUIM,DEPT BIOCHEM BR-05508 SAO PAULO BRAZIL
Titolo Testata:
Free radical biology & medicine
fascicolo: 1, volume: 19, anno: 1995,
pagine: 11 - 19
SICI:
0891-5849(1995)19:1<11:DIOTHR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; AQUEOUS-SOLUTION; INJURY; CHEMILUMINESCENCE; SCAVENGERS; OXIDATION; NITROXIDE; NITRATION; SYSTEMS;
Keywords:
PEROXYNITRITE; PEROXYNITROUS ACID; DESFERRIOXAMINE; HYDROXAMATES; HYDROXYL RADICAL; FREE RADICALS; SPIN TRAPPING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Denicola et al., "DESFERRIOXAMINE INHIBITION OF THE HYDROXYL RADICAL-LIKE REACTIVITY OFPEROXYNITRITE - ROLE OF THE HYDROXAMIC GROUPS", Free radical biology & medicine, 19(1), 1995, pp. 11-19

Abstract

Nitric oxide reacts with superoxide to form peroxynitrite, a strong oxidizing species. Peroxynitrite can either directly oxidize molecules such as thiols or protonate to peroxynitrous acid, which can yield an oxidant with a reactivity similar to that of hydroxyl radical in a transition metal-independent mechanism. This oxidative chemistry of peroxynitrite, however, is inhibited by the metal chelator desferrioxamine. Indeed, desferrioxamine, was a potent inhibitor of dimethylsulfoxide,hydrogen peroxide, 5,5-dimethyl-1-pyrroline-N-oxide, and luminol oxidation, whereas the metal chelator diethylenetriaminepentaacetic acid, and ferrioxamine, the iron complex of desferrioxamine, were not. Two other hydroxamates, acetohydroxamate and salicylhydroxamate, were also effective inhibitors. Stopped-flow experiments showed that there is nodirect reaction between peroxynitrite anion or cis-peroxynitrous acidwith desferrioxamine. Electron paramagnetic resonance (EPR) studies showed the formation of the desferrioxamine nitroxide radical in incubations containing desferrioxamine, but not ferrioxamine, indicating that the hydroxamic group acts as a one-electron donor to peroxynitrite-derived oxidants. Taken together, our results led us to propose that desferrioxamine can inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:08:54