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Titolo:
AEROSOL BOLUS DISPERSION AND EFFECTIVE AIRWAY DIAMETERS IN MILDLY ASTHMATIC-CHILDREN
Autore:
SCHULZ H; SCHULZ A; BRAND P; TUCH T; VONMUTIUS E; ERDL R; REINHARDT D; HEYDER J;
Indirizzi:
GSF,FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT,INST INHALAT BIOL,POB 1129 D-85758 OBERSCHLEISSHEIM GERMANY UNIV MUNICH,KINDERKLIN MUNICH GERMANY UNIV MUNICH,KINDER POLIKLIN MUNICH GERMANY
Titolo Testata:
The European respiratory journal
fascicolo: 4, volume: 8, anno: 1995,
pagine: 566 - 573
SICI:
0903-1936(1995)8:4<566:ABDAEA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPIROMETRY;
Keywords:
AEROSOL BOLUS DISPERSION; AEROSOL-DERIVED AIRWAY MORPHOMETRY; ASTHMA DIAGNOSIS; EARLY CHANGES IN LUNG FUNCTION; PATHOMECHANISMS OF ASTHMA; PULMONARY FUNCTION TESTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H. Schulz et al., "AEROSOL BOLUS DISPERSION AND EFFECTIVE AIRWAY DIAMETERS IN MILDLY ASTHMATIC-CHILDREN", The European respiratory journal, 8(4), 1995, pp. 566-573

Abstract

The contribution of aerosol techniques, the estimation of aerosol bolus dispersion and effective airway dimensions, to the clinical diagnosis of paediatric asthma was studied. In 47 children, aged 11+/-2 yrs, with mild asthma (forced expiratory volume in one second (FEV,) 83+/-9% of forced vital capacity (FVC)) effective airway diameters were derived from the recovery of inhaled 1 mu m sebacate droplets. Intrapulmonary dispersion of inhaled boluses of 0.4 mu m droplets was studied, bycharacterizing the concentration distributions of droplets in the exhaled air by their standard deviation and skewness. Effective airway diameters increased in asthmatic subjects with increasing body size, anddid not differ from those obtained in 16 healthy children of similar age and height. Standard deviation and skewness of particle boluses exhaled from shallow lung depths were higher in the asthmatic children than the healthy children (e.g. standard deviation 91+/-17 ml vs 79+/-15 ml, skewness 0.38+/-0.16 vs 0.23+/-0.16, respectively, for boluses in 140 ml lung depth). The sensitivity and specificity of bolus dispersion to detect alterations in lung function was comparable to that of FEV(1)/FVC, the most sensitive conventional lung function parameter in the present study. There was no correlation between body height or lung function and bolus parameters. We conclude that aerosol measurementsdo not provide an obvious benefit for the clinical diagnosis of mild paediatric asthma, but bolus dispersion supplies additional information on alterations in convective gas transport in the diseased lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:18:41