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Titolo:
INTERVENTION WITH SPINAL NMDA, ADENOSINE, AND NO SYSTEMS FOR PAIN MODULATION
Autore:
GORDH T; KARLSTEN R; KRISTENSEN J;
Indirizzi:
UNIV UPPSALA HOSP,DEPT ANAESTHESIOL,PAIN TREATMENT UNIT S-75185 UPPSALA SWEDEN
Titolo Testata:
Annals of medicine
fascicolo: 2, volume: 27, anno: 1995,
pagine: 229 - 234
SICI:
0785-3890(1995)27:2<229:IWSNAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
R-PHENYLISOPROPYL-ADENOSINE; INTRATHECAL INJECTION; RECEPTORS; MORPHINE; CORD; RAT; ANTAGONISTS; NOCICEPTION; ANESTHESIA; AGONISTS;
Keywords:
ANALGESIA; POSTOPERATIVE; NMDA ANTAGONISTS; ADENOSINE ANALOGS; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Gordh et al., "INTERVENTION WITH SPINAL NMDA, ADENOSINE, AND NO SYSTEMS FOR PAIN MODULATION", Annals of medicine, 27(2), 1995, pp. 229-234

Abstract

Understanding of the complex pharmacology of the spinal cord may leadto rational advances in pain treatment It appears that a number of specific neurochemical mechanisms exist, by which spinally administered receptor selective agents may modify nociceptive transmission. Spinal administration of pure competitive N-methyl-D-aspartate (NMDA) antagonists affects only hyperpathic pain components, i.e. with signs of central sensitization, and most probably has a very limited role in postoperative pain treatment. On the other hand, it is well established thatthe non-competitive NMDA-antagonist ketamine gives good postoperativeanalgesia, probably by cerebral mechanisms also affecting other sensory modalities. Pure adenosine A(1)-receptor agonism at the spinal level mainly affects sensory allodynia to vibration, and is probably no alternative for postoperative pain treatment. In contrast, i.v. infusions of the non-selective A(1)/A(2)-receptor agonist adenosine given during a surgical procedure seem to decrease postoperative pain and requirements for postoperative analgesia. This apparent contradiction must be analysed further. Several drugs commonly used to treat postoperativepain, such as opioids, NSAIDs, ketamine and paracetamol, are linked to nitric oxide (NO) in their mechanism of action. The biosynthesis of NO in the central nervous system (CNS) is tonically involved in the nociceptive processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:04:09