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Titolo:
CORTISOL, CORTICOTROPIN, AND BETA-ENDORPHIN RESPONSES TO CORTICOTROPIN-RELEASING HORMONE IN PATIENTS WITH ATOPIC ECZEMA
Autore:
RUPPRECHT M; HORNSTEIN OP; SCHLUTER D; SCHAFERS HJ; KOCH HU; BECK G; RUPPRECHT R;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT NEUROENDOCRINOL,KRAEPELINSTR 2-10 D-80804 MUNICH GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN,DEPT NEUROENDOCRINOL D-80804 MUNICH GERMANY UNIV ERLANGEN NURNBERG,DEPT DERMATOL D-91052 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT PSYCHIAT D-91054 ERLANGEN GERMANY
Titolo Testata:
Psychoneuroendocrinology
fascicolo: 5, volume: 20, anno: 1995,
pagine: 543 - 551
SICI:
0306-4530(1995)20:5<543:CCABRT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; CUSHINGS-DISEASE; IMMUNE-SYSTEM; DEPRESSION; DERMATITIS; SECRETION; INVITRO; INVIVO; RATS; LEWIS;
Keywords:
CORTICOTROPIN-RELEASING HORMONE (CRH); CORTISOL; CORTICOTROPIN; BETA-ENDORPHIN; ATOPIC ECZEMA; HPA-SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Rupprecht et al., "CORTISOL, CORTICOTROPIN, AND BETA-ENDORPHIN RESPONSES TO CORTICOTROPIN-RELEASING HORMONE IN PATIENTS WITH ATOPIC ECZEMA", Psychoneuroendocrinology, 20(5), 1995, pp. 543-551

Abstract

Alterations in the hypothalamic-pituitary-adrenal (HPA) system are well documented in affective disorders. In depression these include increased secretion of cortisol, an insufficient suppressibility of cortisol by dexamethasone, a blunted corticotropin (ACTH) response to corticotropin-releasing hormone (CRH) and a dysfunction of the glucocorticoid receptor. Patients with atopic eczema, a common chronic skin disease, show seasonal variations in disease activity, symptoms of minor depression and immunological disturbances similar to those seen in patients with depression. To explore the integrity of the HPA system integrity in individuals with atopic eczema we studied the 24-h cortisol secretion and the cortisol, ACTH and beta-endorphin responses to CRH in such individuals and in healthy controls matched for sex and age. The 24-h secretion of cortisol did not differ between the patients with atopic eczema and the controls. The net response to CRH administered as a 100 mu g IV bolus was significantly attenuated for both cortisol (24,235 +/- 12,443 vs. 47,019 +/- 34,515 nmol.min/dl; p < .03) and for ACTH (546 +/- 205 vs. 727 +/- 310 pmol.min/l; p < .05) in the patient group, whereas the beta-endorphin response did not differ between the groups (1072 +/- 448 vs. 1603 +/- 421 nmol.min/l). The blunted response of cortisol and ACTH cannot be explained by hypercortisolism as it is thecase in major depression. Rather, it may be related to a prolonged underexposure to hypothalamic CRH or to an increased sensitivity of glucocorticoid feedback inhibition.

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Documento generato il 04/04/20 alle ore 21:35:34