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Titolo:
ALTERATION OF PHOSPHOLIPASE C-DELTA PROTEIN LEVEL AND SPECIFIC ACTIVITY IN ALZHEIMERS-DISEASE
Autore:
SHIMOHAMA S; FUJIMOTO S; MATSUSHIMA H; TAKENAWA T; TANIGUCHI T; PERRY G; WHITEHOUSE PJ; KIMURA J;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT NEUROL,SAKYO KU,54 SHOGOINKAWAHARACHO KYOTO 606 JAPAN KYOTO PHARMACEUT UNIV,DEPT BIOCHEM KYOTO JAPAN KYOTO PHARMACEUT UNIV,DEPT NEUROBIOL KYOTO JAPAN UNIV TOKYO,INST MED,DEPT ONCOBIOL,MINATO KU TOKYO JAPAN CASE WESTERN RESERVE UNIV HOSP,INST PATHOL,DIV NEUROPATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV HOSP,DEPT NEUROL CLEVELAND OH 44106
Titolo Testata:
Journal of neurochemistry
fascicolo: 6, volume: 64, anno: 1995,
pagine: 2629 - 2634
SICI:
0022-3042(1995)64:6<2629:AOPCPL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; NEUROFIBRILLARY TANGLES; GLUTATHIONE-PEROXIDASE; KINASE-C; DEMENTIA; MESSENGER; BRAIN; QUANTITATION; ACCUMULATION; ISOZYMES;
Keywords:
ALZHEIMERS DISEASE; NEUROFIBRILLARY TANGLES; PHOSPHOLIPASE C-DELTA; ANTIBODY; CONCENTRATION; ACTIVITY; INACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S. Shimohama et al., "ALTERATION OF PHOSPHOLIPASE C-DELTA PROTEIN LEVEL AND SPECIFIC ACTIVITY IN ALZHEIMERS-DISEASE", Journal of neurochemistry, 64(6), 1995, pp. 2629-2634

Abstract

Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in signal transduction. We have previously demonstrated that an antibody toan isozyme of PLC, PLC-delta, produced intense staining of neurofibrillary tangles in the brains of patients with Alzheimer's disease. In the present study, we investigated the protein level and activity of this enzyme in control and Alzheimer brains. Western blot analysis usinga specific antibody for PLC-delta showed that the concentration of PLC-delta protein was significantly higher in the cytosolic fraction of Alzheimer's disease cortical tissue than in control brains. The activity of PLC-delta, which hydrolyzes phosphatidylinositol, was also investigated, and we found that PLC-delta activity was not significantly different in the Alzheimer and control cytosolic fractions. These results indicate that the specific activity of PLC-delta is decreased in Alzheimer brains and suggest that inactivation of PLC-delta might be related to the pathophysiology of this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:44:11