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Titolo:
DISSOCIATIONS IN THE EXPRESSION OF THE SEDATIVE EFFECTS OF TRIAZOLAM
Autore:
WEINGARTNER HJ; SIROCCO K; RAWLINGS R; JOYCE E; HOMMER D;
Indirizzi:
NIAAA,LCS,COGNIT NEUROSCI SECT,BLDG 10,ROOM 3B19,9000 ROCKVILLE PIKE BETHESDA MD 20982 CHARING CROSS & WESTMINSTER MED SCH,ACAD DEPT PSYCHIAT LONDON ENGLAND NIAAA,LCS,BRAIN IMAGING SECT BETHESDA MD 20892
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 119, anno: 1995,
pagine: 27 - 33
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE MEMORY-SYSTEMS; IMPLICIT MEMORY; INDUCED AMNESIA; DIAZEPAM; BENZODIAZEPINES; SCOPOLAMINE; SENSITIVITY; IMPAIRMENTS; VOLUNTEERS; BEHAVIOR;
Keywords:
BENZODIAZEPINES; EXPLICIT MEMORY; REFLECTIVE PROCESSES; SEDATION; TRIAZOLAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Weingartner et al., "DISSOCIATIONS IN THE EXPRESSION OF THE SEDATIVE EFFECTS OF TRIAZOLAM", Psychopharmacology, 119(1), 1995, pp. 27-33

Abstract

Fifteen normal volunteers were administered 0.250, 0.375, and 0.500 mg of triazolam and placebo in a double-blind repeated measures cross-over design. Subjects demonstrated dose-dependent impairments in free recall, a test of explicit memory requiring awareness and reflection, and sedation as assessed by objective behavioral measures (the digit symbol substitution task) and subjective visual analogue scales. The sedative drug response did not account for the impairment in free recall. Differences in performance of the two tests of sedation indicated that the effect of this drug on reflective processes accounts for impairment in episodic memory and the inability to track the sedative effectsof this drug at the higher doses tested in this study.

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Documento generato il 21/09/20 alle ore 06:28:12