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Titolo:
EFFECT OF HYPOXIA ON REFLEX RESPONSES OF TRACHEAL SUBMUCOSAL GLANDS
Autore:
HEJAL R; STROHL KP; EROKWU B; CHERNIACK NS; HAXHIU MA;
Indirizzi:
UNIV CLEVELAND HOSP,DEPT MED,2074 ABINGTON RD CLEVELAND OH 44106 UNIV CLEVELAND HOSP,DEPT MED CLEVELAND OH 44106
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 78, anno: 1995,
pagine: 1651 - 1656
SICI:
8750-7587(1995)78:5<1651:EOHORR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; SODIUM-CYANIDE; BRAIN HYPOXIA; SEROUS CELLS; SECRETION; AIRWAY; MUCOSAL; DOGS; STIMULATION; RECEPTORS;
Keywords:
AIRWAY CONTROL; AIRWAY SECRETIONS; AIRWAY SMOOTH MUSCLE TONE; PULMONARY C-FIBER RECEPTORS; RAPIDLY ADAPTING RECEPTORS; SUBSTANCE P; OXYGEN DEPRIVATION; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Hejal et al., "EFFECT OF HYPOXIA ON REFLEX RESPONSES OF TRACHEAL SUBMUCOSAL GLANDS", Journal of applied physiology, 78(5), 1995, pp. 1651-1656

Abstract

The effects of moderate sustained normocapnic hypoxia on tracheal submucosal gland reflex responses were studied. Experiments were performed in anesthetized, paralyzed, and mechanically ventilated dogs. The changes in the number of secreting glands and volume of secreted fluid in the subsequent period of time were recorded after 15-30 min of controlled ventilation with room air [arterial PO2 (Pa-O2) 86 +/- 3 Torr], hypoxic gas mixture (Pa-O2 49 +/- 4 Torr), or 100% O-2 (Pa-O2 339 +/- 39 Torr), under isocapnic and isohydric conditions. The hillocks method was used to quantify the changes in submucosal gland secretion. The changes in secretion 30 s after stimulation of pulmonary C-fiber receptors by right atrial injection of capsaicin (10 mu g/kg; n = 10) were markedly lower during moderate hypoxia than in normoxia or hyperoxia. Differences in the number of liquid droplets and the volume of secreted fluid were statistically significant (P < 0.05 and P < 0.001, respectively). Stimulation of airway rapidly adapting receptors by lung deflation increased airway secretion; the number of ''hillocks'' and the volume of secreted fluid were lower in hypoxic than in hyperoxic state. Differences between response curves for the number of glands activated and secreted volume were statistically significant (P < 0.05 and P <0.001). The number of glands activated by substance P given locally by arterial infusion was not affected by the state of oxygenation, but the calculated volume of secreted fluid was lower during the hypoxic state than under hyperoxic condition (P = 0.05). When tracheal tension was measured (n = 7), hypoxia-potentiated lung deflation induced tracheal constriction (P < 0.05). These findings suggest that prolonged moderate hypoxia triggers mechanisms that suppress reflex submucosal gland responses and potentiate tracheal smooth muscle reflex contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:50:41