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Titolo:
P53 GENE POINT MUTATIONS IN RELATION TO P53 NUCLEAR-PROTEIN ACCUMULATION IN COLORECTAL CANCERS
Autore:
COSTA A; MARASCA R; VALENTINIS B; SAVARINO M; FARANDA A; SILVESTRINI R; TORELLI G;
Indirizzi:
IST NAZL TUMORI,VIA VENEZIAN 1 I-20133 MILAN ITALY IST NAZL STUDIO & CURA TUMORI I-20133 MILAN ITALY UNIV MODENA,MED CLIN 3,CTR EMATOL SPERIMENTALE I-41100 MODENA ITALY
Titolo Testata:
Journal of pathology
fascicolo: 1, volume: 176, anno: 1995,
pagine: 45 - 53
SICI:
0022-3417(1995)176:1<45:PGPMIR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE BREAST-CANCER; TUMOR-SUPPRESSOR GENE; CELL-PROLIFERATION; POOR PROGNOSIS; BLADDER-CANCER; DNA ANEUPLOIDY; EXPRESSION; CARCINOMAS; OVEREXPRESSION; ASSOCIATION;
Keywords:
P53 MUTATIONS; P53 PROTEIN ACCUMULATION; COLORECTAL CANCER; PATHOLOGICAL AND BIOLOGICAL FEATURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Costa et al., "P53 GENE POINT MUTATIONS IN RELATION TO P53 NUCLEAR-PROTEIN ACCUMULATION IN COLORECTAL CANCERS", Journal of pathology, 176(1), 1995, pp. 45-53

Abstract

It is known that structural alterations of the p53 tumour suppressor gene cause malignant transformation and tumour progression in colorectal mucosa. In this study, 38 colorectal cancers were analysed for mutations detected in the p53 gene by single-strand conformational polymorphism and DNA sequence analysis, and the results were compared with p53 protein expression detected by immunohistochemistry. A very strict association (P<0.0001) was found between genetic alterations and protein accumulation, as detected by the PAb 1801 monoclonal antibody. p53 expression and gene mutations were more frequent in rectal than in colonic cancers. No relation was observed with Dukes' stage, even though most of the mutations were at exon 7 in Dukes' A-B cancers and almost all mutations at exon 8 were observed in Dukes' C-D cancers. DNA ploidywas not generally associated with p53 protein expression or gene mutations. However, 83 per cent of cases with exon 5 and 6 mutations were diploid or near-diploid and 71 per cent of cases with mutations at exons 7 and 8 were aneuploid. Tumours with p53 gene mutations at exon 5 had a higher median [H-3]thymidine labelling index (17 per cent) than those with mutations at exons 6, 7, and 8 (11.8 per cent).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:26:28