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Titolo:
AK-5 TUMOR-INDUCED EXPRESSION OF INTERLEUKIN-12 - ROLE OF IL-12 IN NK-MEDIATED AK-5 REGRESSION
Autore:
HEGDE SP; BRIGHT JJ; KAUSALYA S; KHAR A;
Indirizzi:
CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOLEC BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cellular immunology
fascicolo: 2, volume: 162, anno: 1995,
pagine: 241 - 247
SICI:
0008-8749(1995)162:2<241:ATEOI->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL STIMULATORY FACTOR; NATURAL-KILLER-CELLS; SPONTANEOUS IMMUNOLOGICAL REGRESSION; LYMPHOCYTE MATURATION FACTOR; RECOMBINANT INTERLEUKIN-2; CYTOKINE; IMMUNOTHERAPY; TRANSCRIPTION; PURIFICATION; HISTIOCYTOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Hegde et al., "AK-5 TUMOR-INDUCED EXPRESSION OF INTERLEUKIN-12 - ROLE OF IL-12 IN NK-MEDIATED AK-5 REGRESSION", Cellular immunology, 162(2), 1995, pp. 241-247

Abstract

Spontaneous regression of AK-5, a histiocytic tumor, is mediated by CD3(-), CD8(+) NK cells through ADCC. The onset of AK-5 regression is associated with the induction of humoral immune response and the augmentation of effector function. The mechanism of tumor cell death involves both necrosis and apoptosis. Interleukin-12, a 75-kDa heterodimeric cytokine, has multiple effects on T and NK cells. We have investigatedthe role of IL-12 in the NK cell-mediated AK-5 tumor regression process. Subcutaneous transplantation of AK-5 tumor induced the expression of IL-12 (p35 and p40) message by Day 6-8 in the splenocytes of syngenic rats. Similarly, analysis of serum samples from tumor-bearing animals showed the presence of circulating IL-12 around the same time. Interaction of immune cells with antibody-tagged AK-5 cells in vitro also triggered the expression of IL-12 message and protein by 3 hr. The circulating IL-12 in the sera of tumor-rejecting animals, as well as rIL-12, stimulated NK cell proliferation, expression of CD16 and CD25, andthe activation of NK cell function. These observations suggest that the ability of the AK-5 tumor to induce the endogenous production of IL-12 may be responsible for keeping the NK cells constantly in an activated state, thus demonstrating an efficient mechanism for the completeregression of the tumor. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:48:38