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Titolo:
IN-VITRO EFFECTS OF LOW-CALCIUM PERITONEAL-DIALYSIS SOLUTIONS ON PERITONEAL MACROPHAGE FUNCTIONS
Autore:
KIEFER T; SCHENK U; HUBEL E; WEBER J; METTANG T; PASSLICKDEETJEN J; KUHLMANN U;
Indirizzi:
ROBERT BOSCH KRANKENHAUS,DEPT INTERNAL MED,DIV NEPHROL,AUERBACHSTR 110 D-70376 STUTTGART GERMANY ROBERT BOSCH KRANKENHAUS,DEPT INTERNAL MED,DIV NEPHROL D-70376 STUTTGART GERMANY FRESENIUS AG OBERURSEL GERMANY
Titolo Testata:
American journal of kidney diseases
fascicolo: 5, volume: 25, anno: 1995,
pagine: 751 - 760
SICI:
0272-6386(1995)25:5<751:IEOLPS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; DEPENDENT CHEMI-LUMINESCENCE; RECEPTOR MEDIATED PHAGOCYTOSIS; CYTOSOLIC CA-2+ LEVELS; CHRONIC RENAL-FAILURE; HUMAN-NEUTROPHILS; PARATHYROID-HORMONE; DEFENSE-MECHANISMS; SUPEROXIDE ANION; IONIZED CALCIUM;
Keywords:
PERITONEAL DIALYSIS; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; PERITONEAL MACROPHAGE; LOW CALCIUM; PERITONEAL DIALYSIS SOLUTION; LEUKOCYTE FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
T. Kiefer et al., "IN-VITRO EFFECTS OF LOW-CALCIUM PERITONEAL-DIALYSIS SOLUTIONS ON PERITONEAL MACROPHAGE FUNCTIONS", American journal of kidney diseases, 25(5), 1995, pp. 751-760

Abstract

The use of low-calcium peritoneal dialysis solutions (PDS) for continuous ambulatory peritoneal dialysis is becoming widely accepted to reduce the risk of serum hypercalcemia in patients taking calcium salts as phosphate binders. We compared the in vitro effects of low-calcium PDS (1,000 mu mol calcium/L), calcium-free buffer, and buffers with increasing calcium concentrations (500 to 5,000 mu mol calcium/L) on peritoneal macrophage (PMO) functions. Peritoneal macrophages isolated from 10 continuous ambulatory peritoneal dialysis patients were incubatedin the different solutions and tested for phagocytic and killing capacity, superoxide generation (cytochrome-C reduction and lucigenin-enhanced chemiluminescence), and the rate of myeloperoxidase-dependent oxidative metabolism (luminol-enhanced chemiluminescence). All functions of the PMO incubated in calcium-free buffer were significantly suppressed compared with the PMO incubated in calcium buffers. No dose-dependent increase of a single PMO function could be found after incubating the PMO in calcium buffer with increasing concentrations, Incubation of PMO in otherwise identical PDS containing 1,000, 1,450, or 1,750 mu mol calcium/L did not result in significantly different PMO functions. Acidic PDS (pH 5.3 to 5.5) suppressed all measured PMO functions as compared with their neutralized counterparts (pH 7.4), irrespective of the calcium concentration. Results of our in vitro study show that low-calcium PDS does not suppress PMO functions any more than standard-calcium PDS (1,750 mu mol calcium/L) does. (C) 1995 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:11:11