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Titolo:
PERIPHERAL HYPERALGESIA IN EXPERIMENTAL NEUROPATHY - MEDIATION BY ALPHA-2-ADRENOCEPTORS ON POSTGANGLIONIC SYMPATHETIC TERMINALS
Autore:
TRACEY DJ; CUNNINGHAM JE; ROMM MA;
Indirizzi:
UNIV NEW S WALES,SCH ANAT SYDNEY NSW 2052 AUSTRALIA
Titolo Testata:
Pain
fascicolo: 3, volume: 60, anno: 1995,
pagine: 317 - 327
SICI:
0304-3959(1995)60:3<317:PHIEN->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE INJURY; SAPHENOUS NERVE; RAT MODEL; POSTGANGLIONIC NEURONS; LOOSE LIGATURES; PAIN DISORDERS; SUBSTANCE-P; HAIRY SKIN; C-FIBERS; SENSITIZATION;
Keywords:
PERIPHERAL NEUROPATHY; HYPERALGESIA; ADRENOCEPTOR; SYMPATHETIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Tracey et al., "PERIPHERAL HYPERALGESIA IN EXPERIMENTAL NEUROPATHY - MEDIATION BY ALPHA-2-ADRENOCEPTORS ON POSTGANGLIONIC SYMPATHETIC TERMINALS", Pain, 60(3), 1995, pp. 317-327

Abstract

Rats in which the sciatic nerve is partially transected develop hyperalgesia which is relieved by sympathectomy. We carried out experimentsusing this model of experimental peripheral neuropathy to examine theperipheral mechanisms underlying sympathetically maintained pain. Subcutaneous injection of noradrenaline (NA) into the affected paw exacerbated the hyperalgesia but had no effect in control animals. Injectionof the non-specific alpha-adrenergic blocker phentolamine and the alpha 2-adrenergic blocker yohimbine significantly relieved the hyperalgesia, while injection of the alpha 1-adrenergic blocker prazosin had noeffect. Peripheral injection of the alpha 2-adrenergic agonist clonidine had no significant effect, while injection of the alpha 1-adrenergic agonist phenylephrine produced slight exacerbation of mechanical hyperalgesia. Hyperalgesia was eliminated by peripheral injection of indomethacin into the affected paw. Following a chemical sympathectomy, hyperalgesia was eliminated and injection of NA into the hyperalgesic paw had no effect on pain thresholds. We concluded that NA exacerbates hyperalgesia in this experimental model by acting on alpha 2-adrenoreceptors which are located on post-ganglionic sympathetic terminals. Ourresults are consistent with the proposal (Levine et al. 1986) that activation of these adrenoreceptors brings about an increased release ofprostaglandins which sensitises nociceptors.

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Documento generato il 30/11/20 alle ore 03:17:23