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Titolo:
CHRONIC TREATMENT WITH DIZOCILPINE MALEATE INCREASES THE NUMBER OF STRIATAL NEURONS EXPRESSING THE D-2 RECEPTOR GENE
Autore:
LANNES B; BERNARD V; BLOCH B; MICHELETTI G;
Indirizzi:
FAC MED STRASBOURG,INST PHYSIOL,11 RUE HUMANN F-67085 STRASBOURG FRANCE UNIV BORDEAUX 2,HISTOL EMBRYOL LAB,CNRS,EP 74 F-33076 BORDEAUX FRANCE
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 65, anno: 1995,
pagine: 431 - 438
SICI:
0306-4522(1995)65:2<431:CTWDMI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROENKEPHALIN MESSENGER-RNA; INSITU HYBRIDIZATION HISTOCHEMISTRY; IDENTIFIED STRIATONIGRAL NEURONS; MONOAMINE-DEPLETED MICE; BASAL GANGLIA; RAT STRIATUM; PARKINSONS-DISEASE; SUBSTANCE-P; NMDA-ANTAGONISTS; PHENOTYPICAL CHARACTERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
B. Lannes et al., "CHRONIC TREATMENT WITH DIZOCILPINE MALEATE INCREASES THE NUMBER OF STRIATAL NEURONS EXPRESSING THE D-2 RECEPTOR GENE", Neuroscience, 65(2), 1995, pp. 431-438

Abstract

N-methyl-D-aspartate antagonists have been proposed as potential therapeutic agents in different neurological diseases, including Parkinson's disease. The effects of gene expression of a chronic treatment withthe non-competitive N-methyl-D-aspartate antagonist, dizocilpine maleate (0.8 mg/kg day, per os for 50 days) were analysed in rat striata. Using quantitative in situ hybridization, we measured the messenger RNA expression of the genes encoding D-1, D-2 dopamine receptors, N-methyl-D-aspartate receptor 1 subunit of N-methyl-D-aspartate receptor, preproenkephalin A and substance P. Chronic treatment with dizocilpine maleate induced a moderate but significant increase in messenger RNA ofthe N-methyl-D-aspartate receptor 1 subunit in the striatum and the adjacent cortex, suggesting an action of dizocilpine maleate in these two regions. This treatment did not induce any change in D-1 receptor, preproenkephalin A or substance P messenger RNA content in the striatum, whereas D, receptor messenger RNA was increased in the striatum of treated rats. Microscopic analysis revealed that it was the number of medium-sized neurons expressing D-2 receptor messenger RNA that was significantly enhanced, while the mean amount of message per cell remained unchanged. These results demonstrate that glutamate via N-methyl-D-aspartate receptors, regulates the D-2 receptor gene in striatal neurons. A chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D-2 receptor gene, suggesting a recruiting phenomenon.

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Documento generato il 15/07/20 alle ore 07:02:29