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Titolo:
ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE IN PATIENTS WITH CHRONIC HEPATITIS-B - COMPARISON OF THE EFFICACY IN PATIENTS WITH HIGH AND LOW VIRAL REPLICATION
Autore:
MARCELLIN P; POUTEAU M; LORIOT MA; BOYER N; DEGOS F; CALES P; BETTAN L; BACQ Y; COPPERE H; GRANGE JD; BERNARD PH; DEGOTT C; ERLINGER S; BENHAMOU JP;
Indirizzi:
HOP BEAUJON,SERV HEPATOL,100 BD GEN LECLERC F-92118 CLICHY FRANCE HOP BEAUJON,INSERM,U24 F-92118 CLICHY FRANCE CTR HOSP REG,SERV HEPATOGASTROENTEROL ANGERS FRANCE CTR HOSP INTERCOMMUNAL,SERV HEPATOGASTROENTEROL VILLENEUVE ST GEO FRANCE HOP TROUSSEAU,SERV MALAD APPAREIL DIGEST TOURS FRANCE CTR HOSP REG & UNIV,SERV GASTROENTEROL & HEPATOL ST ETIENNE FRANCE HOP TENON,SERV HEPATOGASTROENTEROL PARIS FRANCE HOP ST ANDRE,SERV MALAD APPAREIL DIGEST BORDEAUX FRANCE HOP BEAUJON,SERV ANAT & CYTOL PATHOL CLICHY FRANCE
Titolo Testata:
Gut
fascicolo: 3, volume: 36, anno: 1995,
pagine: 422 - 426
SICI:
0017-5749(1995)36:3<422:A5IPWC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; ARA-AMP; VIRUS-INFECTION; MONOPHOSPHATE; INTERFERON;
Keywords:
HEPATITIS B VIRUS; PURINE NUCLEOSIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
P. Marcellin et al., "ADENINE-ARABINOSIDE 5'-MONOPHOSPHATE IN PATIENTS WITH CHRONIC HEPATITIS-B - COMPARISON OF THE EFFICACY IN PATIENTS WITH HIGH AND LOW VIRAL REPLICATION", Gut, 36(3), 1995, pp. 422-426

Abstract

This study compared the response to adenine arabinoside 5'-monophosphate (ARA AMP) in 60 patients with chronic hepatitis B according to thepretreatment serum hepatitis B virus DNA concentration. The level of hepatitis B virus replication was defined as low (30 patients) high (30 patients) when serum hepatitis B virus DNA concentration was below or above 100 pg/ml, respectively. Patients received a 28 day course of ARA AMP and a second course of ARA AMP was given six months later to patients with persistent hepatitis B virus replication. At the end of the first course of ARA AMP, 11 of the patients (37%) with low replication and one of the patients (3%) with high replication became negativefor hepatitis B virus DNA (p = 0.0012); five of the patients (17%) with low replication and none of the patients with high replication had HBe seroconversion (p = 0.06). Two of these five patients lost HBsAg. Kinetics of serum hepatitis B virus DNA during treatment showed a considerable but transient antiviral effect of ARA AMP. Three of 32 retreated patients became negative for hepatitis B virus DNA and one patienthad HBe seroconversion. In conclusion, ARA AMP exerts a considerable but transient antiviral effect on hepatitis B virus. Complete and sustained inhibition of hepatitis B virus replication was only obtained inthe patients with low hepatitis B virus replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:20:41