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Titolo:
HUMAN EXPOSURE TO POLYCHLORINATED-BIPHENYLS (PCBS) - A CRITICAL-ASSESSMENT OF THE EVIDENCE FOR ADVERSE HEALTH-EFFECTS
Autore:
SWANSON GM; RATCLIFFE HE; FISCHER LJ;
Indirizzi:
MICHIGAN STATE UNIV,CTR CANC,A-128 E FEE HALL E LANSING MI 48824 MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL E LANSING MI 48824
Titolo Testata:
Regulatory toxicology and pharmacology
fascicolo: 1, volume: 21, anno: 1995,
pagine: 136 - 150
SICI:
0273-2300(1995)21:1<136:HETP(->2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPACITOR MANUFACTURING WORKERS; TRANSFORMER REPAIR WORKERS; YU-CHENG PATIENTS; DICHLORODIPHENYL DICHLOROETHENE DDE; HUMAN ADIPOSE-TISSUE; GREAT-LAKES FISH; ORGANOCHLORINE COMPOUNDS; OCCUPATIONAL EXPOSURE; HUMAN-MILK; BREAST-CANCER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
166
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Swanson et al., "HUMAN EXPOSURE TO POLYCHLORINATED-BIPHENYLS (PCBS) - A CRITICAL-ASSESSMENT OF THE EVIDENCE FOR ADVERSE HEALTH-EFFECTS", Regulatory toxicology and pharmacology, 21(1), 1995, pp. 136-150

Abstract

Results from epidemiologic studies involving human exposures to polychlorinated biphenyls (PCBs) are often used to estimate the potential risk or hazard posed by the presence of these chemicals in the workplace or the environment. The use of results and conclusions from individual studies requires an assessment of the scientific quality of the information contained in published reports. The results of a critical review of the scientific literature reported here should be an aid to those who are interested in risk evaluations surrounding exposures to PCBs. There are diverse approaches that one could take to an evaluation of scientific reports of the health hazards of various chemicals. We present one approach to assessing the strengths and weaknesses of studies conducted to understand the potential association between PCB exposure and human health effects. A comprehensive review of the scientific literature involving human exposures to PCBs was performed and each study was evaluated on the basis of a defined set of criteria that were considered standards in epidemiologic research. Two of the 39 occupational studies reviewed provided positive evidence and 3 suggestive evidence for an exposure-related effect, whereas none of the 33 studies where exposure had occurred in the natural environment provided positiveor suggestive evidence of an association with adverse effects. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:10:42